ArticleEuropean journal of nutrition2022
The DONALD study as a longitudinal sensor of nutritional developments: iodine and salt intake over more than 30 years in German children.
Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Iodine Supplementation Before, During and After Pregnancy.Geburtshilfe und Frauenheilkunde · 2026Article
- Age- and body surface area-specific ultrasound percentile charts for thyroid volume in Polish school-aged children: comparison with European cohorts.Frontiers in endocrinology · 2026Article
- [Iodine status of the population in the WHO European Region (an abridged translation of selected sections of the WHO European report)].Problemy endokrinologii · 2025Review
- Replacing cow's milk with plant-based drinks: consequences for nutrient intake of young children on a balanced diet in Germany.Journal of health, population, and nutrition · 2025Article
- Cohort profile update-overview of over 35 years of research in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study.European journal of nutrition · 2024Review
- Association between urinary iodine excretion, genetic disposition and fluid intelligence in children, adolescents and young adults: the DONALD study.European journal of nutrition · 2023Article
- Unfavorable nutrient intakes in children up to school entry age: results from the nationwide German KiESEL study.Frontiers in nutrition · 2023Article
- Safety of whole seeds of oilseed rape (Brassica napus L emend. Metzg.) as a novel food pursuant to Regulation (EU) 2015/2283.EFSA journal. European Food Safety Authority · 2023Article
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4 authors at 2 institutions in 1 country.
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Abstract
purposeMild-to-moderate iodine deficiency was present in large parts of Germany up to the beginning 1990s and improved from then on. Current epidemiological data on spot urine iodine measurements in German children strongly suggest the re-occurrence of an impaired iodine status. We thus examined whether this re-occurrence is identifiable in more detail, through iodine analyses of 24-h urine samples of a well-characterized cohort of German children in whom samples have been systematically collected from 1985 onward. As iodized salt is a major source for iodine supply, urinary sodium excretion was additionally studied.
methodsDaily iodine and sodium excretions were measured in 2600 24-h urine samples collected between 1985 and 2018 by 677 healthy children aged 6-12 years (participants of the DONALD study). These data were compared with 24-h iodine and sodium excretion estimates obtained from spot urine samples collected in the representative German Health Interview and Examination Surveys for Children and Adolescents KiGGS-baseline (2003-2006) and KiGGS-wave-2 (2014-2017).
resultsBetween 1985 and1992, DONALD participants started with a median daily iodine excretion level of 40.1 µg/d. Then, during 1993-2003, iodine excretions mounted up to an approximate plateau (~ 84.8 µg/d). This plateau lasted until 2012. Thereafter, iodine concentrations started to decrease again resulting in a median iodine excretion of only 58.9 µg/d in 2018. Sodium excretion, however, had increased. The marked decrease in iodine status along with an abundant sodium excretion corresponded closely with nationwide KiGGS data.
conclusionsAs exemplified for the clearly worsening iodine status in German children, longitudinal cohort studies collecting detailed biomarker-based prospective data have the potential to reliably capture health-relevant nutritional changes and trends, applicable on a more comprehensive and even representative population level.
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