ArticleHypertension research : official journal of the Japanese Society of Hypertension2022
Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 21 citations in OpenAlex.
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- Regional effect of population-based programs promoting salt reduction and potassium intake in Hokkaido: a post hoc analysis of the PoSPIP.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association of subjective and objective physical activity with home hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Prediction of future development of hypertension in the general population using urinary Na/K ratio.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- High Estimated 24-Hour Urinary Sodium Excretion is Associated With Metabolic Syndrome and Its Phenotypes: Tehran Lipid and Glucose Study.Journal of nutrition and metabolism · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Does casual urine Na/K ratio predict 24 h urine Na/K ratio in treated hypertensive patients? Comparison between casual urine voided in the morning vs. 24 h urine collected on the previous day.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The association between urine-estimated salt intake and hypertension: findings of a population-based study.Clinical hypertension · 2025Article
- Non-use of dentures after tooth loss is associated with elevated sodium/potassium ratios in older adults: a retrospective cohort study.Frontiers in dental medicine · 2025Article
- Practical use and target value of urine sodium-to-potassium ratio in assessment of hypertension risk for Japanese: Consensus Statement by the Japanese Society of Hypertension Working Group on Urine Sodium-to-Potassium Ratio.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Association between urinary sodium-to-potassium ratio, elevated blood pressure phenotypes and microalbuminuria: Tehran Lipid and Glucose Study.Scientific reports · 2024Article
- Effects of salt intake reduction by urinary sodium to potassium ratio self-monitoring method.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Association of hypertension with noodle consumption among Korean adults based on the Health Examinees (HEXA) study.Nutrition research and practice · 2024Article
- Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study.BMC public health · 2024Article
- Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults.Scientific reports · 2024Article
- 2023 update and perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.Journal of atherosclerosis and thrombosis · 2023Article
- The spot urine sodium-to-potassium ratio as a marker of hypertension risk.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
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24 authors at 4 institutions in 1 country.
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Abstract
The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) ratio is known to have diurnal and day-to-day variations. Therefore, we investigated the number of days required to yield a better association between the morning uNa/K ratio and home BP (HBP) and determined a morning uNa/K ratio value that can be used as a reference value in participants who are not taking antihypertensive medication. This was a cross-sectional study using data from the Tohoku Medical Megabank Project Cohort Study. A total of 3122 participants borrowed HBP and uNa/K ratio monitors for 10 consecutive days. We assessed the relationship between the morning uNa/K ratio from 1 day to 10 days and home hypertension (HBP ≥ 135/85 mmHg) using multiple logistic regression models. Although a 1-day measurement of the morning uNa/K ratio was positively associated with home hypertension, multiple measurements of the morning uNa/K ratio were strongly related to home hypertension. The average morning uNa/K ratio was relatively stable after 3 days (adjusted odds ratio of home hypertension per unit increase in the uNa/K ratio for more than 3 days: 1.19-1.23). In conclusion, there was no threshold for the uNa/K ratio, and the morning uNa/K ratio was linearly associated with home hypertension. The Na/K ratio 2.0 calculated from the Dietary Reference Intakes for Japanese might be a good indication. Regarding the stability of the association between the morning uNa/K ratio and BP, more than 3 days of measurements is desirable.
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