ReviewNature reviews. Endocrinology2022
Primary hypothyroidism and quality of life.
Review in Nature reviews. Endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Treatment Preferences in Patients With Hypothyroidism.The Journal of clinical endocrinology and metabolism · 2025Pooled it
- LT4/LT3 Combination Therapy vs. Monotherapy with LT4 for Persistent Symptoms of Hypothyroidism: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Reply to 'Post-thyrotoxicosis weight gain: time to stratify and treat?'Nature reviews. Endocrinology · 2026Article
- 10.6 μm laser moxibustion can improve oxidative stress and abnormal energy metabolism in liver of hypothyroidism rats through Nrf2/HO-1 and Nrf2/PGC-1α/TFAM pathways.Lasers in medical science · 2026Article
- Quality of life in hypothyroid subjects treated with levothyroxine: a cross-sectional study.Thyroid research · 2026Article
- The association between vitamin D and hypothyroidism: a systematic review and meta-analysis.Nutrition & metabolism · 2026Review
- Thyroid hormone therapy in a population cohort over two decades indicates persistent overtreatment.European thyroid journal · 2026Article
- Investigating the relationship between thyroid replacement therapy goals status and quality of life in patients with primary hypothyroidism.Endocrine · 2026Article
- Resolution of Hashimoto thyroiditis with Janus kinase inhibitor therapy in a patient with alopecia universalis.JCEM case reports · 2026Article
- Differences in thyroid hormone prescribing practices between Japan Thyroid Association-certified thyroid specialists and non-certified members: a nationwide survey in Japan.Endocrine journal · 2026Article
- Systemic inflammatory markers predict mortality in autoimmune thyroiditis: threshold-driven risk stratification and prognostic insights from a nationwide cohort.Hormones (Athens, Greece) · 2026Article
- Association of caspase-3 with thyroid hormone levels in patients with hypothyroidism - A hospital-based study.EJIFCC · 2026Article
- Changes in gut microbiota before and after treatment in patients with primary hypothyroidism.Open life sciences · 2026Article
- PERSPECTIVE: Prioritizing quality of life in the management of hyperthyroidism: an expert clinical perspective.Endocrine connections · 2026Review
- Oral Intake of Plasticizer Di-(2-ethylhexyl) Phthalate Disrupts Cerebellar Myelination via Thyroid Signaling in Aging Mice.Environment & health (Washington, D.C.) · 2025Article
- Canadian Endocrinologists' Perspectives on Treatment With Thyroid Hormone Substitutions in Euthyroid and Hypothyroid Patients: A 2023 THESIS Questionnaire Survey.Clinical endocrinology · 2025Article
- A questionnaire survey of thyroid specialists in Japan on the use of thyroid hormones in hypothyroid and euthyroid patients.Endocrine journal · 2025Article
- Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy.Science advances · 2025Article
- Quality of life in pregnant women with subclinical hypothyroidism: clinical management gaps.Thyroid research · 2025Article
- Prevalence and severity of fatigue in treated hypothyroidism: results of a UK survey.European thyroid journal · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of hypothyroidism. The biochemical definition of subclinical hypothyroidism is a matter of debate. Indiscriminate screening for hypothyroidism has led to overdiagnosis and treatment initiation at lower serum levels of thyroid-stimulating hormone (TSH) than previously. Adverse health effects have been documented in individuals with hypothyroidism or hyperthyroidism, and these adverse effects can affect health-related quality of life (QOL). Levothyroxine substitution improves, but does not always normalize, QOL, especially for individuals with mild hypothyroidism. However, neither studies combining levothyroxine and liothyronine (the synthetic form of tri-iodothyronine) nor the use of desiccated thyroid extract have shown robust improvements in patient satisfaction. Future studies should focus not only on a better understanding of an individual's TSH set point (the innate narrow physiological range of serum concentration of TSH in an individual, before the onset of hypothyroidism) and alternative thyroid hormone combinations and formulations, but also on autoimmunity and comorbidities unrelated to hypothyroidism as drivers of patient dissatisfaction. Attention to the long-term health consequences of hypothyroidism, beyond QOL, and the risks of overtreatment is imperative.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.