ArticleScientific reports2022
Improved acquisition of contact heat evoked potentials with increased heating ramp.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions.Bioactive materials · 2026Review
- Article
- Lower thresholds and stronger adaptation to pain in musicians reflect occupational-specific adaptations to contact heat stimulation.European journal of pain (London, England) · 2025Article
- Short-term effects of transcranial direct current stimulation on pain sensitivity, emotional and cognitive processes in non-suicidal self-injury: a randomised controlled trial.General psychiatry · 2025Article
- The heating rate matters! contact heat evoked potentials in musicians and non-musicians.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Understanding inter-individual variability of experimental pain habituation and conditioned pain modulation in healthy individuals.Scientific reports · 2024Article
- Validity of central pain processing biomarkers for predicting the occurrence of oncological chronic pain: a study protocol.BMC cancer · 2024Article
- Low-Intensity Focused Ultrasound to the Human Dorsal Anterior Cingulate Attenuates Acute Pain Perception and Autonomic Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Contact-Heat Evoked Potentials: Insights into Pain Processing in CRPS Type I.Journal of pain research · 2024Article
- Shedding light on neuropathic pain: Current and emerging tools for diagnosis, screening, and quantification.SAGE open medicine · 2024Review
- Psychophysics of Pain: A Methodological Introduction.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability.bioRxiv : the preprint server for biology · 2023Article
- Confidence of probabilistic predictions modulates the cortical response to pain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain.Brain stimulationArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Contact heat evoked potentials (CHEPs) represent an objective and non-invasive measure to investigate the integrity of the nociceptive neuraxis. The clinical value of CHEPs is mostly reflected in improved diagnosis of peripheral neuropathies and spinal lesions. One of the limitations of conventional contact heat stimulation is the relatively slow heating ramp (70 °C/s). This is thought to create a problem of desynchronized evoked responses in the brain, particularly after stimulation in the feet. Recent technological advancements allow for an increased heating ramp of contact heat stimulation, however, to what extent these improve the acquisition of evoked potentials is still unknown. In the current study, 30 healthy subjects were stimulated with contact heat at the hand and foot with four different heating ramps (i.e., 150 °C/s, 200 °C/s, 250 °C/s, and 300 °C/s) to a peak temperature of 60 °C. We examined changes in amplitude, latency, and signal-to-noise ratio (SNR) of the vertex (N2-P2) waveforms. Faster heating ramps decreased CHEP latency for hand and foot stimulation (hand: F = 18.41, p < 0.001; foot: F = 4.19, p = 0.009). Following stimulation of the foot only, faster heating ramps increased SNR (F = 3.32, p = 0.024) and N2 amplitude (F = 4.38, p = 0.007). Our findings suggest that clinical applications of CHEPs should consider adopting faster heating ramps up to 250 °C/s. The improved acquisition of CHEPs might consequently reduce false negative results in clinical cohorts. From a physiological perspective, our results demonstrate the importance of peripherally synchronizing afferents recruitment to satisfactorily acquire CHEPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.