ArticleNature communications2022
Resolving the structure of phage-bacteria interactions in the context of natural diversity.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 139 citations in OpenAlex.
- Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity.Microbiome · 2024Trial
- Phylogeny-agnostic strain-level prediction of phage-host interactions from genomes using machine learning.Nature microbiology · 2026Article
- Article
- Structural Receptors and Host Adaptations Affecting the Bacteriophage Targeting ofMicroorganisms · 2026Review
- Eradication of catheter-associated MDR Acinetobacter baumannii biofilms mediated by novel phage encoded depolymerase activity.NPJ biofilms and microbiomes · 2026Article
- Phage host range: determinants, dynamics and applications.Nature reviews. Microbiology · 2026Review
- Reliable evaluation and learning in multi-input biological association prediction.Briefings in bioinformatics · 2026Article
- Bacteria-phage coevolution drives variation in bacterial wilt disease incidence via resistance-virulence trade-offs.Nature microbiology · 2026Article
- Eco-evolutionary dynamics of massive, parallel bacteriophage outbreaks in compost communities.Science advances · 2026Article
- The interplay between ecological networks drives host-plasmid community dynamics.PLoS computational biology · 2026Article
- Molecular Insights into Phage-Hydrogel Polymer Interactions Through Docking, Molecular Dynamics, and Machine Learning.Polymers · 2026Article
- Complex temporal dynamics of phage-bacteria populations in an animal-associated marine system.Nature communications · 2026Article
- Microbial diversity as a foundation for biological AI : Learning biology from evolution's largest dataset.EMBO reports · 2026Article
- Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes.PLoS biology · 2026Article
- Phage Stability Across Conditions: Ensuring Accurate Use of Viral Surrogates in Antiviral Testing.Viruses · 2026Article
- Characterization of a Phage vB_LZ 2044 Deriving from K1-Type Hypervirulent Klebsiella pneumoniae Efficient Against Liver Infection Mice Model.Probiotics and antimicrobial proteins · 2026Article
- Density-dependent feedback and higher-order interactions enable coexistence in phage-bacteria community dynamics.The ISME journal · 2026Article
- Genome-guided isolation and characterization of a novel bacteriophage infectingFrontiers in microbiology · 2026Article
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
- A microbiologist's field guide to community ecology.ISME communications · 2026Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial communities are shaped by viral predators. Yet, resolving which viruses (phages) and bacteria are interacting is a major challenge in the context of natural levels of microbial diversity. Thus, fundamental features of how phage-bacteria interactions are structured and evolve in the wild remain poorly resolved. Here we use large-scale isolation of environmental marine Vibrio bacteria and their phages to obtain estimates of strain-level phage predator loads, and use all-by-all host range assays to discover how phage and host genomic diversity shape interactions. We show that lytic interactions in environmental interaction networks (as observed in agar overlay) are sparse-with phage predator loads being low for most bacterial strains, and phages being host-strain-specific. Paradoxically, we also find that although overlap in killing is generally rare between tailed phages, recombination is common. Together, these results suggest that recombination during cryptic co-infections is an important mode of phage evolution in microbial communities. In the development of phages for bioengineering and therapeutics it is important to consider that nucleic acids of introduced phages may spread into local phage populations through recombination, and that the likelihood of transfer is not predictable based on lytic host range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.