Evidence map›Paper›PMID 35042809›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Ethical, legal, and social issues in the Earth BioGenome Project.

Jacob S Sherkow, Katharine B Barker, Irus Braverman, Robert Cook-Deegan, Richard Durbin, Carla L Easter, Melissa M Goldstein, Maui Hudson, W John Kress, Harris A Lewin and 6 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Article
  10. Article
  11. A new species ofIMA fungus · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Standards recommendations for the Earth BioGenome Project.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Darwinian genomics and diversity in the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. The Earth BioGenome Project 2020: Starting the clock.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jacob S SherkowCollege of Law, University of Illinois at Urbana-Champaign, Champaign, IL 61820; jsherkow@illinois.edu.ORCID 0000-0002-9724-9261
Katharine B BarkerGlobal Genome Initiative and Global Genome Biodiversity Network, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560.
Irus BravermanUniversity at Buffalo School of Law, The State University of New York at Buffalo, Buffalo, NY 14260.ORCID 0000-0002-4352-001X
Robert Cook-DeeganSchool for the Future of Innovation in Society and Consortium for Science, Policy & Outcomes, College of Global Futures, Arizona State University, Washington, DC 20006.ORCID 0000-0002-8251-4237
Richard DurbinDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.ORCID 0000-0002-9130-1006
Carla L EasterEducation and Community Involvement Branch, National Human Genome Research Institute, Bethesda, MD 20892.
Melissa M GoldsteinDepartment of Health Policy and Management, Milken Institute School of Public Health, George Washington University, Washington, DC 20052.ORCID 0000-0001-5576-9018
Maui HudsonTe Kotahi Research Institute, University of Waikato, Hamilton 3216, New Zealand.
W John KressThe Arnold Arboretum, Harvard University, Jamaica Plain, MA 02130.ORCID 0000-0002-0140-5267
Harris A LewinDepartment of Evolution and Ecology, College of Biological Sciences, University of California, Davis, CA 95616.ORCID 0000-0002-1043-7287
Debra J H MathewsBerman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-4897-7617
Catherine McCarthyWellcome Sanger Institute, Hinxton CB10 1SA, United Kingdom.
Ann M McCartneyGenome Informatics Section, National Human Genomics Research Institute, Bethesda, MD 20892.
Manuela da SilvaFiocruz Covid-19 Biobank, Fundação Oswaldo Cruz, Rio de Janeiro 21041-361, Brazil.ORCID 0000-0001-6073-8929
Andrew W TorranceSchool of Law, University of Kansas, Lawrence, KS 66045.
Henry T GreelyCenter for Law and the Biosciences, Stanford Law School, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1105-6734

Funding

Wellcome Trust 207492/Z/17/Z
6 · The paper itself

Abstract

The Earth BioGenome Project (EBP) is an audacious endeavor to obtain whole-genome sequences of representatives from all eukaryotic species on Earth. In addition to the project's technical and organizational challenges, it also faces complicated ethical, legal, and social issues. This paper, from members of the EBP's Ethical, Legal, and Social Issues (ELSI) Committee, catalogs these ELSI concerns arising from EBP. These include legal issues, such as sample collection and permitting; the applicability of international treaties, such as the Convention on Biological Diversity and the Nagoya Protocol; intellectual property; sample accessioning; and biosecurity and ethical issues, such as sampling from the territories of Indigenous peoples and local communities, the protection of endangered species, and cross-border collections, among several others. We also comment on the intersection of digital sequence information and data rights. More broadly, this list of ethical, legal, and social issues for large-scale genomic sequencing projects may be useful in the consideration of ethical frameworks for future projects. While we do not-and cannot-provide simple, overarching solutions for all the issues raised here, we conclude our perspective by beginning to chart a path forward for EBP's work.

Indexed as

Ethics, ResearchGenomicsAnimalsBiosecurityEndangered SpeciesHumansbiodiversityEBPELSIethicsgenomics

Identifiers

PMID35042809
PMCPMC8795529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.