ArticleProceedings of the National Academy of Sciences of the United States of America2022
Why sequence all eukaryotes?
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Clustering the protein universe of life using DIAMOND DeepClust.Nature methods · 2026Article
- From Permits to Samples: Addressing Key Challenges for High-Quality Reference Genome Generation in Europe.Molecular ecology resources · 2026Review
- The Earth BioGenome Project Phase II: illuminating the eukaryotic tree of life.Frontiers in science · 2025Article
- Genome assembly of the endangered Santa Marta Harlequin Toad, Atelopus laetissimus, endemic to the Sierra Nevada de Santa Marta of Colombia.The Journal of heredity · 2025Article
- Annotation matters: the effect of structural gene annotation on orthology inference.Bioinformatics (Oxford, England) · 2025Article
- The mitochondrial genome of the steppe carpenter moth (Paracossulus thrips Hübner, 1818): Structural analysis and phylogenetic implications.Scientific reports · 2025Article
- Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors.ACS chemical neuroscience · 2025Review
- Best-practice guidance for Earth BioGenome Project sample collection and processing: progress and challenges in biodiverse reference genome creation.GigaScience · 2025Article
- A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species.GigaScience · 2025Article
- Quality assessment of gene repertoire annotations with OMArk.Nature biotechnology · 2025Article
- Pangenome graphs and their applications in biodiversity genomics.Nature genetics · 2025Review
- OMArk, a tool for gene annotation quality control, reveals erroneous gene inference.Nature biotechnology · 2025Article
- A high quality genome of the common swamp pitcher plant (Nepenthes mirabilis) using PacBio HiFi sequencing.PloS one · 2025Article
- Orphan genes are not a distinct biological entity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Comparative analysis of amphibian genomes: An emerging resource for basic and applied research.Molecular ecology resources · 2025Article
- A Faroese perspective on decoding life for sustainable use of nature and protection of biodiversity.npj biodiversity · 2024Review
- Disentangling cobionts and contamination in long-read genomic data using sequence composition.G3 (Bethesda, Md.) · 2024Article
- HBeeID: a molecular tool that identifies honey bee subspecies from different geographic populations.BMC bioinformatics · 2024Article
- Low-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes.Nature communications · 2024Article
- Review
Corrections and comments
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Authors and funding
27 authors.
Funding
Abstract
Life on Earth has evolved from initial simplicity to the astounding complexity we experience today. Bacteria and archaea have largely excelled in metabolic diversification, but eukaryotes additionally display abundant morphological innovation. How have these innovations come about and what constraints are there on the origins of novelty and the continuing maintenance of biodiversity on Earth? The history of life and the code for the working parts of cells and systems are written in the genome. The Earth BioGenome Project has proposed that the genomes of all extant, named eukaryotes-about 2 million species-should be sequenced to high quality to produce a digital library of life on Earth, beginning with strategic phylogenetic, ecological, and high-impact priorities. Here we discuss why we should sequence all eukaryotic species, not just a representative few scattered across the many branches of the tree of life. We suggest that many questions of evolutionary and ecological significance will only be addressable when whole-genome data representing divergences at all of the branchings in the tree of life or all species in natural ecosystems are available. We envisage that a genomic tree of life will foster understanding of the ongoing processes of speciation, adaptation, and organismal dependencies within entire ecosystems. These explorations will resolve long-standing problems in phylogenetics, evolution, ecology, conservation, agriculture, bioindustry, and medicine.
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