ArticleProceedings of the National Academy of Sciences of the United States of America2022
Yeast has evolved to minimize protein resource cost for synthesizing amino acids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Trade-off between flux efficiency and metabolic control shapes enzyme allocation.Molecular systems biology · 2026Article
- A universal medium bridging the shake-flask to fermenter gap inFrontiers in microbiology · 2026Article
- Amino Acid Frequency in the Proteome Is Not Associated With Realised Thermal Limit nor Dietary Niche Breadth in 35 Lepidoptera Species.Ecology and evolution · 2025Article
- Article
- Lost in translation: conserved amino acid usage despite extreme codon bias in foraminifera.mBio · 2025Article
- Computational biology predicts metabolic engineering targets for increased production of 103 valuable chemicals in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Does metabolic rate influence genome-wide amino acid composition in the course of animal evolution?Evolution letters · 2025Article
- The advances in creating Crabtree-negative Saccharomyces cerevisiae and the application for chemicals biosynthesis.FEMS yeast research · 2025Review
- Differential amino acid usage leads to ubiquitous edge effect in proteomes across domains of life that can be explained by amino acid secondary structure propensities.Scientific reports · 2024Article
- Article
- Omics data analysis reveals the system-level constraint on cellular amino acid composition.Synthetic and systems biotechnology · 2024Article
- Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO Toolbox 3.0.Nature protocols · 2024Review
- Functional decomposition of metabolism allows a system-level quantification of fluxes and protein allocation towards specific metabolic functions.Nature communications · 2023Article
- Biosynthetic constraints on amino acid synthesis at the base of the food chain may determine their use in higher-order consumer genomes.PLoS genetics · 2023Article
- Phenotypic response of yeast metabolic network to availability of proteinogenic amino acids.Frontiers in molecular biosciences · 2022Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Proteins, as essential biomolecules, account for a large fraction of cell mass, and thus the synthesis of the complete set of proteins (i.e., the proteome) represents a substantial part of the cellular resource budget. Therefore, cells might be under selective pressures to optimize the resource costs for protein synthesis, particularly the biosynthesis of the 20 proteinogenic amino acids. Previous studies showed that less energetically costly amino acids are more abundant in the proteomes of bacteria that survive under energy-limited conditions, but the energy cost of synthesizing amino acids was reported to be weakly associated with the amino acid usage in
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