Evidence map›Paper›PMID 35042776›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Eosinophils regulate intra-adipose axonal plasticity.

Xia Meng, Xinmin Qian, Xiaofan Ding, Wenjing Wang, Xia Yin, Guanglei Zhuang, Wenwen Zeng

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Peripheral Neuropathy in Metabolic Stress.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Immunoregulation in cancer-associated cachexia.Journal of advanced research · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xia MengInstitute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-1194-9233
Xinmin QianInstitute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China.
Xiaofan DingInstitute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-0838-5887
Wenjing WangShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Xia YinShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China wenwenzeng@tsinghua.edu.cn zhuangguanglei@gmail.com yinxia2@aliyun.com.
Guanglei ZhuangShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China wenwenzeng@tsinghua.edu.cn zhuangguanglei@gmail.com yinxia2@aliyun.com.
Wenwen ZengInstitute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China; wenwenzeng@tsinghua.edu.cn zhuangguanglei@gmail.com yinxia2@aliyun.com.ORCID 0000-0001-8544-3318
Center for Life Sciences · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sympathetic innervation regulates energy balance, and the nerve density in the adipose tissues changes under various metabolic states, resulting in altered neuronal control and conferring resilience to metabolic challenges. However, the impact of the immune milieu on neuronal innervation is not known. Here, we examined the regulatory role on nerve plasticity by eosinophils and found they increased cell abundance in response to cold and produced nerve growth factor (NGF) in the white adipose tissues (WAT). Deletion of

Indexed as

Adipose TissueAdipose Tissue, WhiteAdultAnimalsAxonsCalciumCell PlasticityEosinophilsFemaleHumansImmunity, InnateInterleukin-33LymphocytesMiceMiddle AgedNerve Growth FactorCalciumInterleukin-33Nerve Growth Factoraxonal plasticityeosinophilsNGFwhite adipose tissues

Identifiers

PMID35042776
PMCPMC8784130
OpenAlexW4205113989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.