ArticleBMJ open diabetes research & care2022
Adiposity and risks of vascular and non-vascular mortality among Chinese adults with type 2 diabetes: a 10-year prospective study.
Article in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 12 citations in OpenAlex.
- Concordance of genetic determinants of acute coronary artery disease between European and Chinese populations.GigaScience · 2026Article
- Type 2 diabetes does not inevitably shorten life expectancy.Military Medical Research · 2026Article
- Dietary patterns and obesity are associated with type 2 diabetes risk in elderly Chinese men: a machine learning approach.Frontiers in nutrition · 2025Article
- Association between sleep behaviors and stroke in Southwest China: a prospective cohort study.BMC public health · 2024Article
- Sialic acids Neu5Ac and KDN in adipose tissue samples from individuals following habitual vegetarian or non-vegetarian dietary patterns.Scientific reports · 2023Article
- Relationship between advanced lung cancer inflammation index and long-term all-cause, cardiovascular, and cancer mortality among type 2 diabetes mellitus patients: NHANES, 1999-2018.Frontiers in endocrinology · 2023Article
- The combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway.BMC veterinary research · 2022Article
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Authors and funding
16 authors at 6 institutions in 2 countries.
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Abstract
introductionAmong individuals with diabetes, high adiposity has been associated with lower cardiovascular disease (CVD) mortality (the so-called 'obesity paradox' phenomenon) in Western populations, for reasons that are still not fully elucidated. Moreover, little is known about such phenomena in Chinese adults with diabetes among whom very few were obese. We aimed to assess the associations of adiposity with vascular and non-vascular mortality among individuals with diabetes, and compare these with associations among individuals without diabetes. RESEARCH DESIGN AND
methodsIn 2004-2008, the prospective China Kadoorie Biobank recruited >512 000 adults from 10 areas in China. After ~10 years of follow-up, 3509 deaths (1431 from CVD) were recorded among 23 842 individuals with diabetes but without prior major diseases at baseline. Cox regression yielded adjusted HRs associating adiposity with mortality.
resultsAmong people with diabetes, body mass index (BMI) (mean 25.0 kg/m
conclusionsAmong relatively lean Chinese adults with diabetes, there were contrasting associations of adiposity with CVD incidence and with mortality. The high mortality risk at low and high BMI levels highlights, if causal, the importance of maintaining normal weight among people with diabetes.
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