SynthesisBMJ open2022
Use of the kidney failure risk equation to inform clinical care of patients with chronic kidney disease: a mixed-methods systematic review.
Synthesis in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Current management of chronic kidney disease in type-2 diabetes-A tiered approach: An overview of the joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) guidelines.Diabetic medicine : a journal of the British Diabetic Association · 2025Guideline
- The kidney failure risk equation in people with CKD and multimorbidity: the effect of competing mortality risks.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Observational
- Development of a Predictive Tool for Maintenance Dialysis Initiation: A Retrospective Cohort Analysis of 589,284 Participants From the Shizuoka Kokuho Database Study.Kidney medicine · 2025Article
- Clinical impact of the Kidney Failure Risk Equation for vascular access planning.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Clinical Outcomes of a Novel Multidisciplinary Care Program in Advanced Kidney Disease (PEAK).Kidney international reports · 2024Article
- Estimates of eskd risk and timely kidney replacement therapy education.BMC nephrology · 2024Observational
- Informed Dialysis Modality Selection Among Veterans With Advanced CKD: A Community-Level Needs Assessment.Kidney medicine · 2024Article
- Kidney Failure Risk Equation Thresholds for Multidisciplinary Kidney Care Referrals: A Validation Study.Kidney medicine · 2024Article
- Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2024Review
- Article
- Clinical Decision Support Tools in the Electronic Medical Record.Kidney international reports · 2024Review
- The kidney failure risk equation predicts kidney failure: Validation in an Australian cohort.Nephrology (Carlton, Vic.) · 2023Article
- Moving Beyond Tools and Building Bridges: Lessons Learned From a CKD Decision Support in Primary Care.Kidney medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE AND
objectiveThe Kidney Failure Risk Equation (KFRE) predicts the risk of end-stage kidney disease in patients with chronic kidney disease (CKD). This study aimed to evaluate the impact of the utility of KFRE in clinical practice. STUDY
designSystematic review. SETTING AND STUDY POPULATIONS: Adult patients with CKD but not receiving renal replacement therapy enrolled in studies where KFRE was used in clinical care pathways. SELECTION CRITERIA FOR STUDIES: All studies published from April 2011 to October 2021 identified from Medline, Cumulative Index to Nursing and Allied Health Literature, Embase and reference and citation searches of included studies. DATA EXTRACTION: Relevant data were extracted, and two reviewers independently assessed study quality using appropriate appraisal tools. ANALYTICAL APPROACH: Findings reported as a narrative synthesis due to heterogeneity of the included studies.
resultsOf 1635 studies identified, 440 duplicates were removed. The remaining 1195 titles and abstracts were screened. All five studies for full-text review were included in the analysis. Three uses of KFRE were assessed: (1) primary to specialty care interface; (2) general nephrology to multidisciplinary care transition; and (3) treatment planning. Evidence of impact on number of patient referrals into nephrology care was conflicting. However, wait times improved in one study. Although KFRE identified high-risk patients for increased multidisciplinary support, there was concern patients stepped down, no longer meeting eligibility criteria, may lack access to services.
conclusionsThis is the first systematic review of studies that have assessed the actual impact of KFRE in clinical practice with five studies of varying quality reported to date. Trials are in progress assessing the impact on clinical outcomes of using KFRE in clinical practice, and KFRE is being incorporated into guidelines for CKD management. Further studies are needed to assess the impact of KFRE on clinical care. TRIAL REGISTRATION NUMBER: Protocol registered on PROSPERO before initiation of the study (Ref: CRD42020219926).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.