Evidence map›Paper›PMID 35042565›Full record

ArticleCardio-oncology (London, England)2022

Influence of extracellular volume fraction on peak exercise oxygen pulse following thoracic radiotherapy.

Justin M Canada, Elisabeth Weiss, John D Grizzard, Cory R Trankle, Leila Rezai Gharai, Franklin Dana, Leo F Buckley, Salvatore Carbone, Dinesh Kadariya, Anthony Ricco and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Justin M CanadaVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA. Justin.M.Canada@vcuhealth.org.ORCID http://orcid.org/0000-0002-1342-7463
Elisabeth WeissDepartment of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.
John D GrizzardDepartment of Radiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Cory R TrankleVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Leila Rezai GharaiDepartment of Radiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Franklin DanaDepartment of Radiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Leo F BuckleyVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Salvatore CarboneVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Dinesh KadariyaVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Anthony RiccoDepartment of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jennifer H JordanVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Ronald K EvansDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Ryan S GartenDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Benjamin W Van TassellDepartment of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
W Gregory HundleyVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Antonio AbbateVCU Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298, USA.
Virginia Commonwealth University · USBrigham and Women's Hospital · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Inflammasome Activity as a Potential Contributor to Uremic CardiomyopathyK23HL150311 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUCKLEY, LEO FRANCIS · 2020 to 2024
$1.1M
NCATS NIH HHS 1UL1TR002649NCATS NIH HHS UL1 TR002649NCI NIH HHS P30 CA016059NHLBI NIH HHS K23 HL150311
6 · The paper itself

Abstract

backgroundRadiation-induced myocardial fibrosis increases heart failure (HF) risk and is associated with a restrictive cardiomyopathy phenotype. The myocardial extracellular volume fraction (ECVF) using contrast-enhanced cardiac magnetic resonance (CMR) quantifies the extent of fibrosis which, in severe cases, results in a noncompliant left ventricle (LV) with an inability to augment exercise stroke volume (SV). The peak exercise oxygen pulse (O

methodsPatients who underwent thoracic radiotherapy for chest malignancies with significant incidental heart dose (≥5 Gray (Gy), ≥10% heart) without a pre-cancer treatment history of HF underwent cardiopulmonary exercise testing to determine O

resultsThirty patients (median [IQR] age 63 [57-67] years, 18 [60%] female, 2.0 [0.6-3.8] years post-radiotherapy) were included. The peak VO

conclusionsIn patients with prior radiotherapy heart exposure, %-predicted O

Indexed as

Cardiorespiratory fitnessExtracellular volume fractionPeak exercise oxygen pulseRadiotherapy

Identifiers

PMID35042565
PMCPMC8764840
OpenAlexW4205703608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.