Evidence map›Paper›PMID 35042563›Full record

ArticleTrials2022

Laparoscopically guided transversus abdominis plane block versus local wound analgesia in laparoscopic surgery for peritoneal endometriosis: study protocol for a prospective randomized controlled double-blinded LTAP-trial.

Anna Terho, Terhi Puhto, Johanna Laru, Outi Uimari, Pasi Ohtonen, Tero Rautio, Sari Koivurova

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04735770 (Laparoscopically Inserted Transversus Abdominis Plane Block Versus Wound Local Anesthesia in Laparoscopic Endometriosis Surgery), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04735770 nacompletednot on this map

Laparoscopically Inserted Transversus Abdominis Plane Block Versus Wound Local Anesthesia in Laparoscopic Endometriosis Surgery: a Prospective Randomized Controlled Double-blinded LTAP-trial

TypeinterventionalSponsorOulu University HospitalRan2021 to 2023Enrolled46ConditionsEndometriosis, Peritoneum, Postoperative PainArmsPostoperative pain management: LTAP block or local wound anesthesia with levobupivacaine
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna TerhoDepartment of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center, University of Oulu, PL 23, 90029 OYS, Oulu, Finland. anna.terho@fimnet.fi.ORCID http://orcid.org/0000-0003-3957-3466
Terhi PuhtoOulu University Hospital and Research unit of Surgery, Anesthesia and Intensive Care, University of Oulu, PL 21, 90029 OYS, Oulu, Finland.
Johanna LaruDepartment of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center, University of Oulu, PL 23, 90029 OYS, Oulu, Finland.
Outi UimariDepartment of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center, University of Oulu, PL 23, 90029 OYS, Oulu, Finland.
Pasi OhtonenOulu University Hospital and Research unit of Surgery, Anesthesia and Intensive Care, University of Oulu, PL 21, 90029 OYS, Oulu, Finland.
Tero RautioOulu University Hospital and Research unit of Surgery, Anesthesia and Intensive Care, University of Oulu, PL 21, 90029 OYS, Oulu, Finland.
Sari KoivurovaDepartment of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center, University of Oulu, PL 23, 90029 OYS, Oulu, Finland.
Oulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUltrasound-guided transversus abdominis plane block (TAP) performed by anesthesiologist has been shown to be an effective and safe analgesia method in abdominal surgery, reducing postoperative opioid consumption. Recently, there has been growing interest to insert TAP under laparoscopic vision (LTAP) by surgeon. LTAP has been used in laparoscopic gastrointestinal surgery, but studies on LTAP in gynecologic laparoscopic surgery are sparse and inconsistent. The purpose of this study is to compare the efficacy of LTAP and local wound analgesia in laparoscopic surgery due to suspected or diagnosed superficial peritoneal endometriosis.

methodsThe LTAP-trial is a prospective randomized controlled double-blinded study comparing the efficacy and safety of LTAP with local wound analgesia in laparoscopic endometriosis surgery. Patients are randomized to receive LTAP with levobupivacaine and wound infiltration with placebo or wound infiltration with levobupivacaine and LTAP with placebo. The primary outcome is postoperative opioid consumption measured by patient-controlled analgesia (PCA) pump. Secondly, subjective postoperative pain up to 24 h postoperatively will be measured by Numeric Rating Scale (NRS). Additional outcome measures are factors related to recovery and length of stay in the hospital as well as a 6-month follow-up survey regarding pain (NRS) and endometriosis-related wellbeing (endometriosis-related health profile, EHP-30) after surgery. A total of 46 patients will be randomized in a proportion of 1:1. DISCUSSION: Patients with peritoneal endometriosis are often prone to severe postoperative pain that may prohibit their enhanced recovery after laparoscopy. Thus, there is a need for effective postoperative pain management with minimal side-effects. This study focusing on laparoscopically inserted transversus abdominis plane block may provide new insight in dealing with postoperative pain after laparoscopic endometriosis surgery as well as after other gynecologic surgery.

trial registrationThe LTAP-trial -protocol has been prospectively registered to ClinicalTrials.gov , ID: NCT04735770 . Registered on February 2021.

Indexed as

EndometriosisLaparoscopyAbdominal MusclesAnalgesia, Patient-ControlledAnalgesics, OpioidAnesthetics, LocalFemaleHumansPostoperative PainProspective StudiesRandomized Controlled Trials as TopicAnalgesics, OpioidAnesthetics, LocalEnhanced recovery after surgeryERASLaparoscopic gynecologic surgeryLTAPPeritoneal endometriosisPostoperative painTransversus abdominis plane block

Identifiers

PMID35042563
PMCPMC8764771
OpenAlexW4205686742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.