ArticleDiabetology & metabolic syndrome2022
Fibrinogen function indexes are potential biomarkers of diabetic peripheral neuropathy.
Article in Diabetology & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 20 citations in OpenAlex.
- A Narrative Review on Abnormalities in the Hemostatic System in Diabetes Mellitus: Pathophysiology, Clinical Implications, and Therapeutics.Life (Basel, Switzerland) · 2026Review
- Predictive value of the fibrinogen-to-high-density lipoprotein cholesterol ratio for sub-clinical diabetic peripheral neuropathy in type 2 diabetes mellitus.Frontiers in aging neuroscience · 2026Article
- The Role of Novel Biomarkers in the Early Management of Peripheral Diabetic Neuropathy.Central nervous system agents in medicinal chemistry · 2026Review
- Stage-dependent alterations of Sonoclot coagulation profiles across the spectrum of diabetic peripheral neuropathy.Frontiers in endocrinology · 2026Article
- Parameters of blood viscoelasticity testing as promising biomarkers for the prediction of the occurrence of diabetic peripheral neuropathy.BMC endocrine disorders · 2025Observational
- The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Article
- Whether coagulation dysfunction influences the onset and progression of diabetic peripheral neuropathy: A multicenter study in middle-aged and aged patients with type 2 diabetes.CNS neuroscience & therapeutics · 2024Article
- Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Association between phase angle and diabetic peripheral neuropathy in Type 2 diabetes patients.Endocrine · 2024Article
- Diagnostic biomarker for type 2 diabetic peripheral neuropathy via comprehensive bioinformatics analysis.Journal of diabetes · 2024Article
- Compound Qiying Granules alleviates diabetic peripheral neuropathy by inhibiting endoplasmic reticulum stress and apoptosis.Molecular medicine (Cambridge, Mass.) · 2023Article
- Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.Frontiers in endocrinology · 2023Article
- The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy.BMC endocrine disorders · 2022Observational
- Increased plasma D-dimer levels may be a promising indicator for diabetic peripheral neuropathy in type 2 diabetes.Frontiers in endocrinology · 2022Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesResearch suggests that diabetic peripheral neuropathy (DPN) is related to plasma fibrinogen (Fib) concentrations, although its correlation with Fib function has not been reported. Here, the k value and angle α, reflecting the plasma Fib function, were used to analyse its correlation with DPN, and their potential as biological indicators for diagnosing DPN was explored. SUBJECTS AND
methodsThis prospective observational clinical study enrolled 561 type 2 diabetes mellitus (T2DM) patients, who were divided into the diabetes with symptomatic neuropathy (161 cases), diabetes with asymptomatic neuropathy (132 cases) and diabetes with no neuropathy (268 cases) groups. Meanwhile, 160 healthy unrelated subjects were recruited as controls.
resultsFib levels increased slightly in diabetic subjects with neuropathy compared with those without. The angle α levels increased slightly in subjects with asymptomatic DPN compared with those with no neuropathy and increased greatly in subjects with symptomatic DPN compared with those without. The k value levels slightly decreased in subjects with asymptomatic DPN compared with those with no neuropathy and greatly decreased in subjects with symptomatic DPN compared with those without. The association of the k value and angle α with diabetic neuropathy was independent of the hyperglycaemic state and other potential confounders (odds ratio 0.080 [0.051-0.124], P < 0.001; odds ratio 1.131 [1.063-1.204], P < 0.001). The k value and angle α levels were closely correlated with neuropathy stage (r = - 0.686, P < 0.000; r = 0.314, P < 0.001). The optimal cut-off point for k value levels to distinguish patients with diabetic neuropathy from those without was 1.8 min, with a sensitivity of 73.7% and a specificity of 83.2% (AUC = 0.873). The optimal cut-off point for angle α levels was 60°, with a sensitivity of 41.0% and a specificity of 95.6% (AUC = 0.669).
conclusionsThe k value and angle α are closely associated with DPN. The levels of the k value and angle α may be helpful in the early diagnosis of DPN.
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