Evidence map›Paper›PMID 35042537›Full record

ArticleRespiratory research2022

MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model.

Xuan Huang, Weijie Guan, Bin Xiang, Wei Wang, Yanqing Xie, Jinping Zheng

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Mucins and Respiratory Virus Infection.Annual review of virology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xuan HuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, No 151 Yanjiang Road, Guangzhou, 510120, People's Republic of China.ORCID http://orcid.org/0000-0001-9845-4921
Weijie GuanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, No 151 Yanjiang Road, Guangzhou, 510120, People's Republic of China.
Bin XiangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, No 151 Yanjiang Road, Guangzhou, 510120, People's Republic of China.
Wei WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, No 151 Yanjiang Road, Guangzhou, 510120, People's Republic of China.
Yanqing XieState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, No 151 Yanjiang Road, Guangzhou, 510120, People's Republic of China.
Jinping ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, No 151 Yanjiang Road, Guangzhou, 510120, People's Republic of China. jpzhenggy@163.com.ORCID http://orcid.org/0000-0002-7511-661X
First Affiliated Hospital of Guangzhou Medical University · CN

Funding

National Natural Science Foundation of China 81470234National Natural Science Foundation of China 82070039
6 · The paper itself

Abstract

backgroundAirway mucus hypersecretion is one of the important pathological features of chronic obstructive pulmonary disease (COPD). MUC5B is the main mucin expressed in the airways of COPD patients and has been indicated to play an important role in airway defense. However, the specific biological function of MUC5B in COPD and the possible mechanism are not clear.

methodsWe established a COPD model with 24-week-old MUC5B

resultsCompared with MUC5B

conclusionThe protective effect of MUC5B in the development of COPD was mediated by the promotion of goblet cell differentiation and the inhibition of inflammation. The role of MUC5B in regulating inflammation was related to macrophage function, and goblet cell differentiation was promoted by the induced expression of STAT6 and SPDEF. This study describes a mechanism of mucus hypersecretion and identifies MUC5B as a new target for the treatment of mucus hypersecretion.

Indexed as

Gene Expression RegulationAnimalsBronchoalveolar Lavage FluidCell DifferentiationDisease Models, AnimalInflammationLungMaleMiceMice, Inbred C57BLMice, KnockoutMucin-5BPulmonary Disease, Chronic ObstructiveRNAMuc5b protein, mouseMucin-5BRNACOPDGoblet cell differentiationInflammationMUC5BSPDEF

Identifiers

PMID35042537
PMCPMC8764756
OpenAlexW4206003991

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.