Evidence map›Paper›PMID 35042530›Full record

ArticleBMC veterinary research2022

Application of Bayesian modeling for diagnostic assays of Mycobacterium avium subsp. paratuberculosis in sheep and goats flocks.

Zahra Hemati, Eleftherios Meletis, Abdollah Derakhshandeh, Masoud Haghkhah, Polychronis Kostoulas, Shoor Vir Singh, Kundan Kumar Chaubey, Saurabh Gupta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Zahra HematiDepartment of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Eleftherios MeletisFaculty of Public and One (Integrated) Health, School of Health Sciences, University of Thessaly, 43100, Karditsa, Greece.
Abdollah DerakhshandehDepartment of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. drkhshnd77@gmail.com.
Masoud HaghkhahDepartment of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Polychronis KostoulasFaculty of Public and One (Integrated) Health, School of Health Sciences, University of Thessaly, 43100, Karditsa, Greece.
Shoor Vir SinghDepartment of Biotechnology, Institute of Applied Sciences and Humanities, GLA University, Ajhai, Mathura, Uttar Pradesh, 281406, India.
Kundan Kumar ChaubeyDepartment of Biotechnology, Institute of Applied Sciences and Humanities, GLA University, Ajhai, Mathura, Uttar Pradesh, 281406, India.
Saurabh GuptaDepartment of Biotechnology, Institute of Applied Sciences and Humanities, GLA University, Ajhai, Mathura, Uttar Pradesh, 281406, India.
GLA University · INShiraz University · IRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to screen the sera of goats and sheep from flocks suspected of Mycobacterium avium subsp. paratuberculosis (MAP) infection by a newly standardized Mce-truncated ELISA (Mt-ELISA) kit for the detection of antibodies against MAP. Four diagnostic applied tests were evaluated including Indigenous plate-ELISA (IP-ELISA), Mt-ELISA, fecal Polymerase Chain Reaction (f-PCR) and fecal culture (FC). MATERIALS AND

methodsAssuming the absence of a gold standard, latent-class models in a Bayesian framework were used to estimate the diagnostic accuracy of the four tests for MAP.

resultsMt-ELISA had higher Sensitivity (Se) in sheep (posterior median: 0.68 (95% Probability Interval (PI): 0.43-0.95), while IP-ELISA recorded the highest Se in goats as 0.83 (95% PI, 0.61-0.97). The f-PCR Se estimate slightly differed between species [sheep 0.36 (0.19-0.58), goats 0.19 (0.08-0.35)], while the Se of FC was similar between species [sheep 0.29 (0.15-0.51), goats 0.27 (0.13-0.45)]. The specificity estimates for all tests were high, close to unity, and similar between species.

conclusionOverall, the results showed that the Mt-ELISA method can be used for MAP detection in small ruminants' flocks.

Indexed as

Goat DiseasesMycobacterium avium subsp. paratuberculosisParatuberculosisSheep DiseasesAnimalsBayes TheoremEnzyme-Linked Immunosorbent AssayFecesGoatsSensitivity and SpecificitySheepBayesian latent class modelsCultureIP-ELISAMt-ELISAParatuberculosisPCR-IS900/413Small ruminantsTest evaluation

Identifiers

PMID35042530
PMCPMC8764775
OpenAlexW4205493811

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.