ArticleReproductive health2022
Fertility trends and comparisons in a historical cohort of US women with primary infertility.
Article in Reproductive health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Role of hormone testing in assessment of infertility.Canadian family physician Medecin de famille canadien · 2026Article
- Discrimination, social support, and mental health in reproductive-aged women: the All of Us research program.BMC women's health · 2026Article
- Risks of Long-Term Psychiatric Disease in Women with a History of Primary Infertility: A Historical Cohort Study.The Psychiatric quarterly · 2024Article
- How great thou ART: biomechanical properties of oocytes and embryos as indicators of quality in assisted reproductive technologies.Frontiers in cell and developmental biology · 2024Review
- Factors associated with caesarean sections among pregnant women admitted to a private academic hospital in Ongwediva, Oshana region, Namibia.Journal of public health in Africa · 2023Article
- Exposure to perfluoroalkyl substances and women's fertility outcomes in a Singaporean population-based preconception cohort.The Science of the total environment · 2023Article
- Programmed frozen embryo transfer cycles are associated with a higher risk of abnormal placental development: a retrospective cohort study of singleton live births.Frontiers in endocrinology · 2023Article
- Women With a History of Primary Infertility and Increased Rates of Bilateral Oophorectomy.Obstetrics and gynecology · 2022Article
- Real-world prescription patterns for reproductive assistance patients in China: A trend analysis from 2016 to 2020.Frontiers in pharmacology · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThere is growing interest in long-term outcomes following infertility and infertility treatment. However, there are few detailed longitudinal cohorts available for this work. This study aimed to assemble a historical cohort of women with primary infertility and age-matched controls to evaluate fertility trends, sequelae, and sociodemographic differences. Described here are cohort group characteristics and associated reproductive trends over time.
methodsA population-based historical cohort was created using the Rochester Epidemiology Project (REP) record-linkage system (Olmsted County, MN). The cohort included women aged 18-50 with a diagnosis of primary infertility between January 1, 1980, and December 31, 1999. As part of a case-control study, we identified 1:1 age-matched female controls from the same community and era.
resultsA total of 1001 women with primary infertility and 1001 age-matched controls were identified. The women with primary infertility were significantly more likely to be married, college educated, use barrier contraception, and non-smokers compared to age-matched controls. The incidence of primary infertility increased from 14 to 20 per 10,000 person years from 1980-1985 to 1995-1999. Ovulatory dysfunction and unexplained infertility were the most common causes of primary infertility and clomiphene was the most widely used fertility medication. Rates of in vitro fertilization (IVF) increased from 1.8% during 1980-1985 to 26.0% during 1995-1999.
conclusionWomen with primary infertility were found to have unique sociodemographic characteristics compared to age-matched control women, which is consistent with previous research. The incidence of diagnosed primary infertility increased from 1980 to 1999, as did use of IVF.
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