Evidence map›Paper›PMID 35042478›Full record

ArticleBMC microbiology2022

Distribution, characterization, and antibiotic resistance of hypervirulent Klebsiella pneumoniae isolates in a Chinese population with asymptomatic bacteriuria.

Jun Li, Yanbing Li, Mengli Tang, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Jingyi Zhang, Mingxiang Zou

Open access · goldAbstract read
In one paragraph

Article in BMC microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Shared resistance and virulence ofOpen veterinary journal · 2025
    Article
  6. Genetic and Functional Analysis of theMicrobiology spectrum · 2023
    Article
  7. Review
  8. The Klebsiella pneumoniaeInfection and immunity · 2023
    Article
  9. Molecular and clinical characterization of hypervirulentFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jun LiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yanbing LiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Mengli TangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Fengjun XiaDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Changhang MinDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yongmei HuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Haichen WangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Jingyi ZhangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Mingxiang ZouDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. zoumingxiang@csu.edu.cn.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsymptomatic bacteriuria (ASB) frequently occurs among all ages and may develop into urinary tract infections (UTIs). Hypervirulent Klebsiella pneumoniae (hvKP) has become a new threat to human health. In our study, we aimed to investigate the epidemiological characteristics of hvKP in population with ASB.

resultsA total of 61 K. pneumoniae isolates were collected from 7530 urine samples between October and December 2020. The strains were sensitive to most of the antimicrobial agents tested, but a polymyxin resistant strain was found (MIC>16 μg/mL). Three serotypes were detected, including K1 (16.4%, 10/61), K5 (1.6%, 1/61) and K57 (3.2%, 2/61). Four strains (KPNY9, KPNY31, KPNY40, and KPNY42) carried a combination of two or more hypervirulent markers (peg-344, iroB, iucA,

conclusionsThe hvKP with relatively weak biofilm formation was detected in a population with ASB, which was more likely to cause bacteremia and serious consequences. A novel sequence type (ST5559) hvKP derived from ST86 was found. Therefore, hvKP should be monitored in the population with ASB.

Indexed as

Drug Resistance, Multiple, BacterialAdultAnimalsAsian PeopleAsymptomatic InfectionsBacteriuriaBiofilmsFemaleHumansKlebsiella InfectionsKlebsiella pneumoniaeLarvaMaleMicrobial Sensitivity TestsMiddle AgedMothsVirulence FactorsAntimicrobial susceptibilityAsymptomatic bacteriuriaBiofilm formationHypervirulent K. pneumoniaeVirulence-associated genesWhole-genome sequencing (WGS)

Identifiers

PMID35042478
PMCPMC8764819
OpenAlexW4205594696

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.