Evidence map›Paper›PMID 35042404›Full record

ArticleOpen biology2022

Daughter centrioles assemble preferentially towards the nuclear envelope in

Neil H J Cunningham, Imène B Bouhlel, Paul T Conduit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Neil H J CunninghamDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Imène B BouhlelDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.ORCID 0000-0001-5876-4597
Paul T ConduitDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.ORCID 0000-0002-7822-1191
University of Cambridge · GBCentre National de la Recherche Scientifique · FR

Funding

Biotechnology and Biological Sciences Research Council BB/P019188/1Wellcome Trust 105653/Z/14/Z
6 · The paper itself

Abstract

Centrosomes are important organizers of microtubules within animal cells. They comprise a pair of centrioles surrounded by the pericentriolar material, which nucleates and organizes the microtubules. To maintain centrosome numbers, centrioles must duplicate once and only once per cell cycle. During S-phase, a single new 'daughter' centriole is built orthogonally on one side of each radially symmetric 'mother' centriole. Mis-regulation of duplication can result in the simultaneous formation of multiple daughter centrioles around a single mother centriole, leading to centrosome amplification, a hallmark of cancer. It remains unclear how a single duplication site is established. It also remains unknown whether this site is pre-defined or randomly positioned around the mother centriole. Here, we show that within

Indexed as

CentriolesDrosophila ProteinsAnimalsCentrosomeDrosophilaNuclear EnvelopeDrosophila Proteinscentriolecentriole duplicationcentrosomeDrosophilamicrotubules

Identifiers

PMID35042404
PMCPMC8767211
OpenAlexW4225563649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.