ArticleJournal of the Royal Society, Interface2022
Effective connectivity determines the critical dynamics of biochemical networks.
Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of Boolean network models reveals design principles of gene regulatory networks.Science advances · 2024Pooled it
- Canalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective.NPJ systems biology and applications · 2026Review
- Attractors are less stable than their basins: Canalization creates a coherence gap in gene regulatory networks.bioRxiv : the preprint server for biology · 2025Article
- CANA v1.0.0: efficient quantification of canalization in automata networks.Bioinformatics (Oxford, England) · 2025Article
- Upper bound for the stability of Boolean networks.Physical review. E · 2025Article
- Quantifying edge relevance for epidemic spreading via the semi-metric topology of complex networks.Journal of physics. Complexity · 2025Article
- An open problem: Why are motif-avoidant attractors so rare in asynchronous Boolean networks?Journal of mathematical biology · 2025Article
- Challenges and opportunities for digital twins in precision medicine from a complex systems perspective.NPJ digital medicine · 2025Review
- Canalization reduces the nonlinearity of regulation in biological networks.NPJ systems biology and applications · 2024Article
- Models of Cell Processes are Far from the Edge of Chaos.PRX life · 2023Article
- The nonlinearity of regulation in biological networks.NPJ systems biology and applications · 2023Article
- Effective Connectivity and Bias Entropy Improve Prediction of Dynamical Regime in Automata Networks.Entropy (Basel, Switzerland) · 2023Article
- The effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Living systems comprise interacting biochemical components in very large networks. Given their high connectivity, biochemical dynamics are surprisingly not chaotic but quite robust to perturbations-a feature C.H. Waddington named canalization. Because organisms are also flexible enough to evolve, they arguably operate in a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.