ArticlePloS one2022
Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Incidence of acute pancreatitis among hospitalized patients with dengue: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2026Pooled it
- Expanded Dengue and the Digestive System: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2026Review
- Role of Cellular Mechanisms in Dengue Pathogenesis: Focus on Immune Cells Interactions.Combinatorial chemistry & high throughput screening · 2026Review
- Dengue and Acute Pancreatitis: A Systematic Review.Tropical medicine and infectious disease · 2025Review
- Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis.Frontiers in immunology · 2025Article
- Dengue pancreatitis with ketoacidosis-a rare manifestation in Endemicity.Oxford medical case reports · 2024Article
- Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation.Investigative ophthalmology & visual science · 2023Article
- The Innate Immune Response in DENV- and CHIKV-Infected Placentas and the Consequences for the Fetuses: A Minireview.Viruses · 2023Review
- Uncovering the potential pathological mechanism of acute pancreatitis in patients with COVID-19 by bioinformatics methods.World journal of emergency medicine · 2023Article
- Liver immunopathogenesis in fatal cases of dengue in children: detection of viral antigen, cytokine profile and inflammatory mediators.Frontiers in immunology · 2023Article
- Immunopathology of Renal Tissue in Fatal Cases of Dengue in Children.Pathogens (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue viral (DENV) infections can lead to acute pancreatitis and associated tissue damage. This study examined the pancreas from two fatal cases of DENV for histopathological changes as well as for the detection of cytokines, and other inflammatory mediators. Tissue sections were prepared for examination by ultrastructural and histopathological techniques. Sections from the pancreas of non-infected individuals were prepared in parallel as a control. The presence of viral replication in macrophages was detected by co-staining for the proteins NS3 and CD68 by immunofluorescence. Immunohistochemistry was used to detect cells that expressed cytokines and inflammatory mediators to characterize the inflammatory response. Edema, acinar necrosis and fibrosis areas associated with a mononuclear infiltrate were found in infected tissues. The major site of virus replication appeared to be macrophages based on their exclusive presentation of the viral protein NS3. Pancreatic tissues from the infected individuals also displayed increased levels of high mobility group box-1, caspase-3, gelatinase B and tumor necrosis factor alpha compared to controls. The presence of virus replicating macrophages in the pancreas was associated with multiple changes in tissue structure that included elevated levels of cytokines and inflammatory markers that may differentiate acute pancreatitis due to DENV infections from other causes.
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Registered trials
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