Evidence map›Paper›PMID 35041504›Full record

ArticleAntimicrobial agents and chemotherapy2022

Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones

Hyun Kim, Shigetarou Mori, Tsuyoshi Kenri, Yasuhiko Suzuki

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hyun KimDepartment of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.ORCID 0000-0002-7439-5231
Shigetarou MoriDepartment of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Tsuyoshi KenriDepartment of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Yasuhiko SuzukiDivision of Bioresources, Hokkaido Universitygrid.39158.36 International Institute for Zoonosis Control, Sapporo, Japan.
National Institute of Infectious Diseases · JPHokkaido University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Buruli ulcer disease is a neglected necrotizing and disabling cutaneous tropical illness caused by Mycobacterium ulcerans. Fluoroquinolone (FQ), used in the treatment of this disease, has been known to act by inhibiting the enzymatic activities of DNA gyrase. However, the detailed molecular basis of these characteristics and the FQ resistance mechanisms in M. ulcerans remains unknown. This study investigated the detailed molecular mechanism of M. ulcerans DNA gyrase and the contribution of FQ resistance

Indexed as

Mycobacterium ulceransQuinolonesDNA GyraseDrug Resistance, BacterialFluoroquinolonesMicrobial Sensitivity TestsMolecular Docking SimulationMutationDNA GyraseFluoroquinolonesQuinolonesBuruli ulcer diseaseDNA gyrasefluoroquinolone resistancemolecular docking studyMycobacterium ulceranssupercoiling assay

Identifiers

PMID35041504
PMCPMC9017346
OpenAlexW4220691922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.