Evidence map›Paper›PMID 35041502›Full record

ArticleAntimicrobial agents and chemotherapy2022

Proteomic Correlates of Enhanced Daptomycin Activity following β-Lactam Preconditioning in Daptomycin-Resistant, Methicillin-Resistant Staphylococcus aureus.

Cassandra Lew, Molly Pellitteri Hahn, Cameron Scarlett, Aaron Rottier, Andrew D Berti, Richard A Proctor, Arnold S Bayer, Warren E Rose

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. β-Lactam Adjunctive Therapy Compared to Vancomycin or Daptomycin Monotherapy in Adult Patients With Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cassandra LewSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-9289-5910
Molly Pellitteri HahnSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Cameron ScarlettSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Aaron RottierSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Andrew D BertiDepartment of Pharmacy Practice, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, Michigan, USA.
Richard A ProctorDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Arnold S BayerThe Lundquist Institute-Harbor UCLA Medical Center, Torrance, California, USA.
Warren E RoseSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-5012-5993
University of Wisconsin–Madison · USEugene Applebaum College of Pharmacy and Health Sciences · USUniversity of California, Los Angeles · US

Funding

Mechanisms and use of penicillin-binding protein inhibition to optimize cationic peptide anti-MRSA treatmentR01AI132627 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ROSE, WARREN E · 2017 to 2021
$2.1M
NIAID NIH HHS R01 AI132627
6 · The paper itself

Abstract

Clinical treatment options for daptomycin (DAP)-resistant (DAP-R), methicillin-resistant Staphylococcus aureus (MRSA) infections are relatively limited. Current therapeutic strategies often take advantage of potential synergistic activity of DAP plus β-lactams; however, the mechanisms underlying their combinatorial efficacy are likely complex and remain incompletely understood. We recently showed that

Indexed as

DaptomycinMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial Agentsbeta-LactamsHumansMicrobial Sensitivity TestsProteomicsAnti-Bacterial Agentsbeta-LactamsDaptomycindaptomycinMRSAproteomicsβ-lactams

Identifiers

PMID35041502
PMCPMC8923230
OpenAlexW4205200807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.