Evidence map›Paper›PMID 35041497›Full record

ArticleJournal of bacteriology2022

Direct Inhibition of RetS Synthesis by RsmA Contributes to Homeostasis of the

Jodi M Corley, Peter Intile, Timothy L Yahr

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jodi M CorleyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USAgrid.214572.7.ORCID 0000-0002-7734-7331
Peter IntileDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USAgrid.214572.7.
Timothy L YahrDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USAgrid.214572.7.ORCID 0000-0001-9054-8704
University of Iowa · US

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Translational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4M
Post-transcriptional regulation of Pseudomonas virulence gene expressionR01AI097264 · NIAID · UNIVERSITY OF IOWA · PI WOLFGANG, MATTHEW C, YAHR, TIMOTHY L · 2013 to 2016
$1.5M
BLRD VA I01 BX002042NHLBI NIH HHS T32 HL007171NIAID NIH HHS R01 AI097264NIDDK NIH HHS P30 DK054759NIH HHS AI097264
6 · The paper itself

Abstract

The Gac/Rsm system is a global regulator of Pseudomonas aeruginosa gene expression. The primary effectors are RsmA and RsmF. Both are RNA-binding proteins that interact with target mRNAs to modulate protein synthesis. RsmA/RsmF recognize GGA sequences presented in the loop portion of stem-loop structures. For repressed targets, the GGA sites usually overlap the ribosome binding site (RBS) and RsmA/RsmF binding inhibits translation initiation. RsmA/RsmF activity is controlled by several small non-coding RNAs (sRNA) that sequester RsmA/RsmF from target mRNAs. The most important sequestering sRNAs are RsmY and RsmZ. Transcription of

Indexed as

Bacterial ProteinsPseudomonas aeruginosaRepressor ProteinsRNA-Binding ProteinsHomeostasisRNA, BacterialRNA, MessengerBacterial ProteinsRepressor ProteinsRetS protein, Pseudomonas aeruginosaRNA, BacterialRNA-Binding ProteinsRNA, MessengerGacAGacShomeostasisPseudomonas aeruginosaRetSRsmARsmFRsmYRsmZ

Identifiers

PMID35041497
PMCPMC8923221
OpenAlexW4206286682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.