ReviewCirculation2022
E-Cigarettes and Cardiopulmonary Health: Review for Clinicians.
Review in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Electronic cigarettes and cardiovascular outcomes: a systematic review and meta-analysis of Major Adverse Cardiovascular Events (MACE).BMC public health · 2026Pooled it
- Prevalence and determinants of e-cigarette use in South Asia: a systematic review.BMJ global health · 2025Pooled it
- Interpersonal communication and perceived norms as social influence mechanisms of e-cigarette use among adults: a systematic review.The American journal of drug and alcohol abuse · 2024Pooled it
- Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes.NEJM evidence · 2024Pooled it
- Trial
- Electronic cigarette use and risk of incident rheumatoid arthritis and systemic lupus erythematosus in the all of us research program.Seminars in arthritis and rheumatism · 2026Article
- FTO/m6A Regulate Prenatal Nicotine-Induced eNOS Uncoupling and BP Susceptibility.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Migration-driven exposome reconfiguration: a predictive, preventive and personalized medicine perspective on cardiometabolic risk.The EPMA journal · 2026Review
- Adipose extracellular vesicles carrying miR-210-3p drive macrophage inflammation and nicotine-induced atherosclerosis.iScience · 2026Article
- Cardiovascular Consequences of E-Cigarettes: A New Challenge for Cardiologists.Journal of clinical medicine · 2026Review
- Lifestyle factors and cardiometabolic risk.Chinese medical journal · 2026Review
- Oxidative stress mediates cardiac electrophysiological injury in inhalation exposure to flavored vaping products.Heart rhythm · 2026Article
- Examining eating disorder symptoms and sex as moderators of the association between the sensory attributes and appeal of e-cigarettes.Journal of psychiatric research · 2026Article
- E-cigarettes and cardiovascular health: a review of components, mechanisms, and clinical risk.American journal of cardiovascular disease · 2026Review
- Acute respiratory and ocular effects of electronic cigarettes: A pre-post experimental study in healthy users.Tobacco prevention & cessation · 2026Article
- Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe.Annual review of pharmacology and toxicology · 2026Review
- Biochemical Alterations Related to Vascular Injury in Smokers: Evidence from Nitric Oxide, Malondialdehyde, Nicotinic Acetylcholine Receptors, and Cotinine.Vascular health and risk management · 2026Article
- Multidimensional exposure architecture shapes vaping-associated transcriptomic dysregulation in oral epithelium.Frontiers in oncology · 2026Article
- Cardiac Autonomic Dysfunction and Increased Oxidative Stress in Conventional Cigarettes and E-Cigarettes: Heart Rate Variability as a Cardiovascular Predictor.Antioxidants (Basel, Switzerland) · 2025Review
- E-Cigarette Use Among Older Adults with Chronic Spinal Cord Injury: Relationship With History of Cigarette Smoking.Archives of rehabilitation research and clinical translation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Electronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. Recent clinical trials suggest that e-cigarette use with counseling may be effective in reducing cigarette use but not nicotine dependence. However, meta-analyses of observational studies demonstrate that e-cigarette use is not associated with smoking cessation. Cardiovascular studies reported sympathetic activation, vascular stiffening, and endothelial dysfunction, which are associated with adverse cardiovascular events. The majority of pulmonary clinical trials in e-cigarette users included standard spirometry as the primary outcome measure, reporting no change in lung function. However, studies reported increased biomarkers of pulmonary disease in e-cigarette users. These studies were conducted in adults, but >30% of high school-age adolescents reported e-cigarette use. The effects of e-cigarette use on cardiopulmonary endpoints in adolescents and young adults remain unstudied. Because of adverse clinical findings and associations between e-cigarette use and increased incidence of respiratory diseases in people who have never smoked, large longitudinal studies are needed to understand the risk profile of e-cigarettes. Consistent with the Centers for Disease Control and Prevention recommendations, clinicians should monitor the health risks of e-cigarette use, discourage nonsmokers and adolescents from using e-cigarettes, and discourage smokers from engaging in dual use without cigarette reduction or cessation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.