Evidence map›Paper›PMID 35041295›Full record

ReviewBrain and behavior2022

Rapid cycling bipolar disorder: Literature review on pharmacological treatment illustrated by a case report on ketamine.

Alexis Bourla, Florian Ferreri, Thomas Baudry, Vincent Panizzi, Vladimir Adrien, Stéphane Mouchabac

Abstract readCase ReportsReview
In one paragraph

Review in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexis BourlaSorbonne Université, AP-HP, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.ORCID 0000-0003-1438-5733
Florian FerreriSorbonne Université, AP-HP, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.
Thomas BaudrySorbonne Université, AP-HP, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.
Vincent PanizziSorbonne Université, AP-HP, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.
Vladimir AdrienSorbonne Université, AP-HP, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.
Stéphane MouchabacSorbonne Université, AP-HP, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRapid cycling bipolar disorder (RCBD) is defined as four or more affective episodes (depression, mania or hypomania) within 1 year. RCBD has a high point of prevalence (from 10% to 20% among clinical bipolar samples) and is associated with greater severity, longer illness duration, worse global functioning and higher suicidal risk, but there is no consensus on treatment option. The use of several pharmacological agents has been reported (levothyroxine, antipsychotics, antidepressants and mood stabilizers).

objectiveThe main objective of this review was to propose a critical review of the literature and to rank the pharmacological agent using a level of evidence (LEO) adapted from the Center for Evidence-Based Medicine, and to illustrate it with a case report on off-label intravenous ketamine.

methodWe conducted a review using the MeSH terms and keywords (bipolar [Title/Abstract]) AND (rapid [Title/Abstract]) AND (cycling [Title/Abstract]) AND (treatment [Title/Abstract]). Alexis Bourla and Stéphane Mouchabac screened 638 documents identified through literature search in Medline (PubMed) or by bibliographic references and 164 abstracts were then analyzed. Nonpharmacological treatments were excluded.

resultSeventy articles were included in the review and divided into six categories: mood stabilizers, antipsychotics, hormonal treatments, ketamine and other pharmacological treatments. DISCUSSION: Our review highlights the heterogeneity of the pharmacological treatment of RCBD and no clear consensus can emerge.

Indexed as

Antipsychotic AgentsBipolar DisorderKetamineAnticonvulsantsAntidepressive AgentsAntimanic AgentsHumansAnticonvulsantsAntidepressive AgentsAntimanic AgentsAntipsychotic AgentsKetamineketaminepharmacological treatmentrapid cycling bipolar disorderreview

Identifiers

PMID35041295
PMCPMC8865164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.