ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022
Mechanistic Insights on the Mechanosynthesis of Phenytoin, a WHO Essential Medicine.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients.ChemSusChem · 2025Article
- An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education.Ultrasonics sonochemistry · 2025Article
- Meeting the UN Sustainable Development Goals with Mechanochemistry.Angewandte Chemie (International ed. in English) · 2024Review
- The Transformation of Inorganic to Organic Carbonates: Chasing for Reaction Pathways in Mechanochemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- From Inert to Catalytically Active Milling Media: Galvanostatic Coating for Direct Mechanocatalysis.Angewandte Chemie (International ed. in English) · 2022Article
- The Mechanochemical Synthesis and Activation of Carbon-Rich π-Conjugated Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Mechanistic Insights on the Mechanosynthesis of Phenytoin, a WHO Essential Medicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- From amines to (form)amides: a simple and successful mechanochemical approach.Beilstein journal of organic chemistry · 2022Article
- Phenytoin-associated movement disorder: A literature review.Tzu chi medical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
In recent years, mechanochemistry has enriched the toolbox of synthetic chemists, enabling faster and more sustainable access to new materials and existing products, including active pharmaceutical ingredients (APIs). However, molecular-level understanding of most mechanochemical reactions remains limited, delaying the implementation of mechanochemistry in industrial applications. Herein, we have applied in situ monitoring by Raman spectroscopy to the mechanosynthesis of phenytoin, a World Health Organization (WHO) Essential Medicine, enabling the observation, isolation, and characterization of key molecular-migration intermediates involved in the single-step transformation of benzil, urea, and KOH into phenytoin. This work contributes to the elucidation of a reaction mechanism that has been subjected to a number of interpretations over time and paints a clear picture of how mechanosynthesis can be applied and optimized for the preparation of added-value molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.