Evidence map›Paper›PMID 35041104›Full record

ArticleWiener medizinische Wochenschrift (1946)2023

Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and the risk of cervical cancer.

Jasenka Wagner, Sanela Štibi, Nikica Selak, Ilija Alvir, Ivica Mamić, Luka Marcelić, Lucija Šušnjar, Mario Puljiz, Marija Heffer, Damir Danolić

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In one paragraph

Article in Wiener medizinische Wochenschrift (1946), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Role ofJournal of clinical medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jasenka WagnerDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Osijek, Osijek, Croatia.
Sanela ŠtibiDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Osijek, Osijek, Croatia.
Nikica SelakDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Osijek, Osijek, Croatia.
Ilija AlvirDepartment of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Ilica 197, 10000, Zagreb, Croatia.
Ivica MamićDepartment of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Ilica 197, 10000, Zagreb, Croatia.
Luka MarcelićDepartment of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Ilica 197, 10000, Zagreb, Croatia.
Lucija ŠušnjarDepartment of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Ilica 197, 10000, Zagreb, Croatia. lucija105@gmail.com.
Mario PuljizDepartment of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Ilica 197, 10000, Zagreb, Croatia.
Marija HefferDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Osijek, Osijek, Croatia.
Damir DanolićDepartment of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Ilica 197, 10000, Zagreb, Croatia.
University Hospital Centre Zagreb · HRUniversity of Osijek · HR

Funding

Faculty of Medicine in Osijek No.2018-VIF-12
6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate the relationships between interleukin 10 (IL10) (rs1800896) and interleukin 1B (IL1B) (rs16944) genetic polymorphisms and the risk for cervical cancer in a cohort of women from Croatia.

methodsA case-control study of 81 patients with cervical cancer and 80 age-matched healthy controls was performed. We collected peripheral blood samples, extracted deoxiribonucleic acid (DNA), and analyzed two single-nucleotide polymorphisms (SNPs) rs1800896 and rs16944 using TaqMan assays (Fa. Thermo Fisher Scientific, Waltham, MA, USA) and real-time polymerase chain reaction (PCR). We investigated a possible association between two cytokine genetic polymorphisms and the occurrence of cervical cancer.

resultsOur results showed no significant difference in the frequency of IL10 (rs1800896) and IL1B (rs16944) genotypes between the patients and the controls (χ2 test, P < 0.05).

conclusionIn this study, no association was found between IL10 rs1800896 and IL1B rs16944 polymorphisms and cervical cancer development.

Indexed as

Interleukin-10Uterine Cervical NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansInterleukin-1betaInterleukinsPolymorphism, Single NucleotideInterleukin-10Interleukin-1betaInterleukinsChronic inflammationCytokinesGenesImmune responseSingle-nucleotide polymorphism

Identifiers

PMID35041104
OpenAlexW4206273841

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.