ReviewSeminars in immunopathology2022
The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic.
Review in Seminars in immunopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
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- Correlation of ocular surface function with sleep quality, anxiety, and depression in patients with dry eye disease.World journal of psychiatry · 2026Article
- Inflammatory marker dynamics in shift work sleep disorder: a data-driven approach among rotating shift workers.Frontiers in neuroscience · 2026Article
- Clocking immunity: circadian modulation of NK cells and emerging timing perspectives.Frontiers in immunology · 2026Review
- The association between anxiety symptoms and sleep quality in people living with HIV/AIDS: the mediating effect of social support, psychological resilience and coping strategies.Frontiers in psychiatry · 2026Article
- Relationship between CXCR4 and GNG4 in the Brain and Chronic Stress-Induced Atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Circadian Clock: A Regulator of Immunity in Autoimmune Diseases.Immunity, inflammation and disease · 2025Review
- Increased Frequency of the Non-Dipper Blood Pressure Pattern in Patients with Systemic Sclerosis: Insights from 24-Hour Ambulatory Monitoring.Journal of personalized medicine · 2025Article
- Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications.Frontiers in immunology · 2025Review
- Insomnia increases the risk for specific autoimmune diseases: a large-scale retrospective cohort study.Frontiers in network physiology · 2025Article
- Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cells.European journal of immunology · 2024Article
- Association between sleep traits and risk of colorectal cancer: a bidirectional Mendelian randomization study.Journal of gastrointestinal oncology · 2024Article
- The temporal expression pattern of classical MHC class I in sleep-restricted mice: Generalizations and broader implications.Brain, behavior, & immunity - health · 2024Article
- Circadian protein expression patterns in healthy young adults.Sleep health · 2024Article
- Shorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Relationship between disease activity index and sleep disorders in children with inflammatory bowel diseases.European journal of pediatrics · 2023Article
- Inflammatory Response: A Crucial Way for Gut Microbes to Regulate Cardiovascular Diseases.Nutrients · 2023Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-four-hour rhythms in immune parameters and functions are robustly observed phenomena in biomedicine. Here, we summarize the important role of sleep and associated parameters on the neuroendocrine regulation of rhythmic immune cell traffic to different compartments, with a focus on human leukocyte subsets. Blood counts of "stress leukocytes" such as neutrophils, natural killer cells, and highly differentiated cytotoxic T cells present a rhythm with a daytime peak. It is mediated by morning increases in epinephrine, leading to a mobilization of these cells out of the marginal pool into the circulation following a fast, beta2-adrenoceptor-dependent inhibition of adhesive integrin signaling. In contrast, other subsets such as eosinophils and less differentiated T cells are redirected out of the circulation during daytime. This is mediated by stimulation of the glucocorticoid receptor following morning increases in cortisol, which promotes CXCR4-driven leukocyte traffic, presumably to the bone marrow. Hence, these cells show highest numbers in blood at night when cortisol levels are lowest. Sleep adds to these rhythms by actively suppressing epinephrine and cortisol levels. In addition, sleep increases levels of immunosupportive mediators, such as aldosterone and growth hormone, which are assumed to promote T-cell homing to lymph nodes, thus facilitating the initiation of adaptive immune responses during sleep. Taken together, sleep-wake behavior with its unique neuroendocrine changes regulates human leukocyte traffic with overall immunosupportive effects during nocturnal sleep. In contrast, integrin de-activation and redistribution of certain leukocytes to the bone marrow during daytime activity presumably serves immune regulation and homeostasis.
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