Evidence map›Paper›PMID 35041046›Full record

Trial reportEuropean journal of nutrition2022

Bioequivalence of long-chain omega-3 polyunsaturated fatty acids from foods enriched with a novel vegetable-based omega-3 delivery system compared to gel capsules: a randomized controlled cross-over acute trial.

Welma Stonehouse, Bradley Klingner, Rachel Tso, Pey Sze Teo, Netsanet Shiferaw Terefe, Ciarán G Forde

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04610983 (Bioavailability of Omega-3 Long-chain Polyunsaturated Fatty Acids), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04610983 phase2unknown statusnot on this map

Bioavailability of Omega-3 Long-chain Polyunsaturated Fatty Acids (LCPUFA) From Foods Enriched With Vegetable-encapsulated Omega-3 Oils

TypeinterventionalSponsorCommonwealth Scientific and Industrial Research Organisation, AustraliaRan2020 to 2021Enrolled24ConditionsLifestyleArmsExperimental: Control, Experimental: Treatment 1 - Semi-Solid food matrix, Treatment 2 - Solid food matrix
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Welma StonehouseCommonwealth Scientific Industrial Research Organisation (CSIRO), Health and Biosecurity, PO Box 10041, Adelaide, BC, SA, 5000, Australia. welma.stonehouse@csiro.au.ORCID http://orcid.org/0000-0002-2856-4962
Bradley KlingnerCommonwealth Scientific Industrial Research Organisation (CSIRO), Health and Biosecurity, PO Box 10041, Adelaide, BC, SA, 5000, Australia.
Rachel TsoClinical Nutrition Research Centre, A*STAR Singapore Institute of Food and Biotechnology Innovation, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5084-1703
Pey Sze TeoClinical Nutrition Research Centre, A*STAR Singapore Institute of Food and Biotechnology Innovation, Singapore, Singapore.ORCID http://orcid.org/0000-0002-7325-9959
Netsanet Shiferaw TerefeCommonwealth Scientific Industrial Research Organisation (CSIRO), Agriculture and Food, Werribee, VIC, Australia.ORCID http://orcid.org/0000-0003-3094-2624
Ciarán G FordeClinical Nutrition Research Centre, A*STAR Singapore Institute of Food and Biotechnology Innovation, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4001-9182
Agency for Science, Technology and Research · SGCSIRO Health and Biosecurity · AUCommonwealth Scientific and Industrial Research Organisation · AU

Funding

1st singapore-australia bilateral programme on "innovations in food for precision health" A19D4b0089
6 · The paper itself

Abstract

purposeTo evaluate bioavailability of omega-3 long-chain polyunsaturated fatty acids (LCPUFA) from foods enriched with novel vegetable-based encapsulated algal oil across Australian and Singaporean populations.

methods27 men (n = 12 Australian European; n = 15 Singaporean Chinese), 21-50 yr; 18-27.5 kg/m

resultsPlasma iAUC

conclusionThe vegetable-based omega-3 LCPUFA delivery system did not affect bioavailability of omega-3 LCPUFA in healthy young Australian and Singaporean men as assessed after a single meal over 24 h, nor was bioavailability affected by ethnicity. This novel delivery system may be an effective way to fortify foods/beverages with omega-3 LCPUFA.

trial registrationThe trial was registered with clinicaltrials.gov (NCT04610983), date of registration, 22 November 2020.

Indexed as

Docosahexaenoic AcidsFatty Acids, Omega-3AustraliaCapsulesDietary SupplementsEicosapentaenoic AcidHumansMaleSingle-Blind MethodTherapeutic EquivalencyVegetablesCapsulesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Algal oilBioavailabilityBioequivalenceDocosahexaenoic acidOmega-3 long-chain polyunsaturated fatty acidsVegetable-based delivery system

Identifiers

PMID35041046
PMCPMC9106597
OpenAlexW4205912520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.