Evidence map›Paper›PMID 35040776›Full record

ArticleeLife2022

Therapeutic downregulation of

Yoichiro Shibuya, Akishige Hokugo, Hiroko Okawa, Takeru Kondo, Daniel Khalil, Lixin Wang, Yvonne Roca, Adam Clements, Hodaka Sasaki, Ella Berry and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Designing and Evaluating Circadian Experiments on Mouse Skin.The Journal of investigative dermatology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Frontiers in medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Yoichiro Shibuya *Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.ORCID 0000-0002-0558-5154
Akishige Hokugo *Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.ORCID 0000-0002-7097-3364
Hiroko OkawaWeintraub Center for Reconstructive Biotechnology, Los Angeles, United States.
Takeru KondoWeintraub Center for Reconstructive Biotechnology, Los Angeles, United States.
Daniel KhalilRegenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.
Lixin WangRegenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.
Yvonne RocaRegenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.
Adam ClementsRegenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.
Hodaka SasakiWeintraub Center for Reconstructive Biotechnology, Los Angeles, United States.
Ella BerryRegenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.
Ichiro NishimuraWeintraub Center for Reconstructive Biotechnology, Los Angeles, United States.ORCID 0000-0002-3749-9445
Reza JarrahyRegenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.ORCID 0000-0003-2518-4697
Regenerative Medicine Institute · MXTohoku University · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attempts to minimize scarring remain among the most difficult challenges facing surgeons, despite the use of optimal wound closure techniques. Previously, we reported improved healing of dermal excisional wounds in circadian clock neuronal PAS domain 2 (

Indexed as

Down-RegulationAnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineCell MovementCicatrixCollagen Type IDrug DiscoveryFemaleFibroblastsGranulation TissueHigh-Throughput Screening AssaysHumansMiceMice, Inbred C57BLBasic Helix-Loop-Helix ProteinsCollagen Type INerve Tissue ProteinsNpas2 protein, mouseSmall Molecule Librariesclock genefibroblasthigh‐throughput screeningmedicinemouseregenerative medicineskinstem cellswound healing

Identifiers

PMID35040776
PMCPMC8789286
OpenAlexW4220749839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.