Evidence map›Paper›PMID 35040691›Full record

ArticleEnvironmental health perspectives2022

Prenatal Exposure to Air Pollution and Autism Spectrum Disorder: Sensitive Windows of Exposure and Sex Differences.

Md Mostafijur Rahman, Yu-Hsiang Shu, Ting Chow, Frederick W Lurmann, Xin Yu, Mayra P Martinez, Sarah A Carter, Sandrah P Eckel, Jiu-Chiuan Chen, Zhanghua Chen and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026
    Article
  15. Prenatal Exposure to Wildfire and Autism in Children.Environmental science & technology · 2026
    Article
  16. Prenatal exposure to wildfire-related PMEnvironment international · 2026
    Article
  17. Prenatal ozone exposure and risk of intellectual disability.Journal of exposure science & environmental epidemiology · 2026
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Md Mostafijur RahmanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA.
Yu-Hsiang ShuDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Ting ChowDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.ORCID 0000-0001-6175-1818
Frederick W LurmannSonoma Technology, Inc., Petaluma, California, USA.ORCID 0000-0001-9943-4172
Xin YuSpatial Science Institute, USC, Los Angeles, California, USA.ORCID 0000-0001-5118-2324
Mayra P MartinezDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.ORCID 0000-0002-6134-606X
Sarah A CarterDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.ORCID 0000-0001-6575-3482
Sandrah P EckelDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA.
Jiu-Chiuan ChenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA.
Zhanghua ChenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA.
Pat LevittDepartment of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, Keck School of Medicine, Saban Research Institute, Children's Hospital Los Angeles, USC, Los Angeles, California, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Rob McConnellDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA.
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Kaiser Permanente · USUniversity of Southern California · USChildren's Hospital of Los Angeles · USHarvard University · USSonoma Technology (United States) · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
The Impact of Air Pollution Exposure on COVID-19 Severity and MortalityR01ES029963 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI MCCONNELL, ROB S, XIANG, ANNY H · 2019 to 2022
$3.3M
Effects of air pollution and gestational diabetes on autismR56ES028121 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI XIANG, ANNY H · 2017 to 2017
$250k
NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES029963NIEHS NIH HHS R56 ES028121
6 · The paper itself

Abstract

backgroundStudies have shown that air pollution exposures during pregnancy are associated with an increased risk of autism spectrum disorder (ASD) in children, and the risk appears to be greater for boys. However, studies assessing gestational windows of susceptibility have been mostly limited by trimesters.

objectiveWe identified sensitive windows of exposure to regional air pollution and risk of ASD and examined sex differences in a large birth cohort.

methodsThis population-based retrospective cohort study included 294,937 mother-child pairs with singleton deliveries in Kaiser Permanente Southern California (KPSC) hospitals from 2001 to 2014. Children were followed using electronic medical records until clinical ASD diagnosis, non-KPSC membership, death, or 31 December 2019, whichever came first. Weekly mean fine particulate matter [PM with an aerodynamic diameter of

resultsThere were 5,694 ASD diagnoses (4,636 boys, 1,058 girls). Sensitive

conclusionsExposures to

Indexed as

Air PollutantsAir PollutionAutism Spectrum DisorderPrenatal Exposure Delayed EffectsFemaleHumansMalePregnancyRetrospective StudiesSex CharacteristicsAir Pollutants

Identifiers

PMID35040691
PMCPMC8765363
OpenAlexW4226154181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.