ArticleVeterinary medicine and science2022
Listeria innocua isolated from diseased ruminants harbour minor virulence genes of L. monocytogenes.
Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Growth phase-specific induction of a viable but nonculturable (VBNC) state inMicrobiology spectrum · 2026Article
- Whole-Genome Sequence Profiling of Listeria innocua From Different Sources: Implications for Public Health.MicrobiologyOpen · 2026Article
- Genomic Features and Antimicrobial Susceptibility ofFoods (Basel, Switzerland) · 2026Article
- Benzalkonium Chloride Tolerance AmongPathogens (Basel, Switzerland) · 2026Article
- Interactive networks of donors and recipients of the TetM gene and its evolutionary dynamics across the bacterial domain.Scientific reports · 2025Article
- First draft genome sequence data report ofData in brief · 2025Article
- Identification and characterization of Listeria monocytogenes and Listeria innocua in bovine listeriosis cases in Uruguay.Tropical animal health and production · 2025Article
- Phage-Based Control ofViruses · 2025Review
- Comparison of fluorescent antibody test, immunohistochemistry, and PCR testing for diagnostic confirmation of neurolisteriosis in 25 goats.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Genomic Characterization ofMicroorganisms · 2024Article
- Genetic diversity and known virulence genes inVeterinary and animal science · 2023Article
- Chemical and Biological Studies ofAntibiotics (Basel, Switzerland) · 2023Article
- Molecular characterization ofFrontiers in cellular and infection microbiology · 2023Article
- Whole-genome sequencing ofFrontiers in microbiology · 2023Article
- Preharvest Environmental and Management Drivers of Multidrug Resistance in Major Bacterial Zoonotic Pathogens in Pastured Poultry Flocks.Microorganisms · 2022Article
- Listeria innocua isolated from diseased ruminants harbour minor virulence genes of L. monocytogenes.Veterinary medicine and science · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeriosis is one of the most common nervous diseases in ruminants, and is caused almost exclusively by the Gram-positive bacterium, Listeria monocytogenes. However, there are few reports of listeriosis associated with L. innocua, which is genetically closely related to L. monocytogenes, but considered non-pathogenic. In this work, we report two cases of suppurative meningoencephalitis in apparently previously healthy ruminants from different farms, in which two strains of L. innocua were recovered. The whole genomes from both isolates were sequenced, allowing phylogenetic analyses to be performed, which indicated that the two strains were very closely related. Virulence determinants were searched, especially genes coding for the main L. monocytogenes virulence factors which have been previously described in L. innocua. Surprisingly, the two isolates do not possess such virulence determinants. Instead, both strains carried a set of genes that encode for other virulence factors of the genus Listeria detected using the Virulence Factor Database (VFDB): iap (division and invasion of host cells), lpeA (entry into non-professional phagocytes cells), fbpA (multifunctional virulence factor, including adherence to host cells), lspA (surface protein anchoring), lap (adhesion to enterocytes and trans epithelial translocation), pdgA (resistance to lysozyme), oatA (resistance to different antimicrobial compounds and also required for growth inside macrophages), lplA1 (use of host-metabolites for in vivo growth), gtcA (catalyses teichoic acid of bacterial wall), prsA2 (cell invasion, vacuole lysis and intracellular growth), clpC, clpE and clpP (survival under several stress conditions). These genes among others detected, could be involved in the ability of L. innocua to produce damage in animal and human hosts. These results highlight the multifactorial profile of Listeria pathogenesis and the need for comprehensive scientific research that address microbiological, environmental and veterinary aspects of listeriosis.
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