Evidence map›Paper›PMID 35040256›Full record

ArticleJournal of cellular and molecular medicine2022

Mitophagy-regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction.

Chunling Xu, Yangpo Cao, Ruxia Liu, Lei Liu, Weilin Zhang, Xuan Fang, Shi Jia, Jingjing Ye, Yingying Liu, Lin Weng and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  9. Review
  10. Autophagy: a double-edged sword in ischemia-reperfusion injury.Cellular & molecular biology letters · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Chunling XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.ORCID 0000-0002-7767-7605
Yangpo CaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Ruxia LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Lei LiuState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Weilin ZhangState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xuan FangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Shi JiaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Jingjing YeDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Yingying LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Lin WengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Xue QiaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Bo LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Ming ZhengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Peking University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy including mitophagy serves as an important regulatory mechanism in the heart to maintain the cellular homeostasis and to protect against heart damages caused by myocardial infarction (MI). The current study aims to dissect roles of general autophagy and specific mitophagy in regulating cardiac function after MI. By using Beclin1

Indexed as

Heart DiseasesMyocardial InfarctionAnimalsMembrane ProteinsMiceMitochondriaMitochondrial ProteinsMitophagyFUNDC1 protein, mouseMembrane ProteinsMitochondrial Proteinsacute myocardial infarctionautophagyBeclin1Fundc1mitophagy

Identifiers

PMID35040256
PMCPMC8831983
OpenAlexW4206046216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.