ArticleEnvironmental science and pollution research international2022
Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat.
Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Impact of microplastics on female reproductive health: insights from animal and human experimental studies: a systematic review.Archives of gynecology and obstetrics · 2025Pooled it
- Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- The Effects of Microplastics and Trace Elements on Ovarian Function and Pathology: A Literature Review.International journal of molecular sciences · 2026Review
- Review
- Current Evidence Linking Microplastic Exposure and Reproductive Cancers.Journal of xenobiotics · 2026Review
- Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.International journal of molecular sciences · 2026Review
- Ovarian toxic effects of micro- and nanoplastics (Review).Experimental and therapeutic medicine · 2026Review
- A review of the impact of micro- and nanoplastics on female reproduction: What we know and gaps in knowledge.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Proteomics reveal serum biomarkers for early diagnosis in premature ovarian insufficiency.Frontiers in endocrinology · 2026Article
- Microplastics and female infertility: reproductive toxicity and underlying mechanisms.Frontiers in endocrinology · 2026Review
- Microplastic-induced multi-organ toxicity: cellular mechanisms and critical roles of organ crosstalk.Frontiers in public health · 2026Review
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Plastic Pollution and Child Health: A Narrative Review of Micro- and Nanoplastics, Additives, and Developmental Risks.Journal of clinical medicine · 2025Review
- Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro.Journal of assisted reproduction and genetics · 2025Article
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.bioRxiv : the preprint server for biology · 2025Article
- Forever particles: histochemistry in the plasticene age.European journal of histochemistry : EJH · 2025Review
- Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn's disease human duodenum-chip models.Journal of hazardous materials · 2025Article
- Microplastics: A threat to Fetoplacental unit and Reproductive systems.Toxicology reports · 2025Review
- Polystyrene Microplastics-Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes.Veterinary medicine and science · 2025Article
- Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective.Journal of pharmaceutical analysis · 2025Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics (MPs) are ubiquitous environmental contaminants; through their physicochemical properties, they can have potentially negative effects on the environment as well as on animal and human health. Studies addressing the toxicity of MPs on mammalian female reproduction are almost absent. Thus, the main objective of the present study was to assess the impact of oral exposure, during four estrous cycles, of 5 µm polystyrene-type microplastics (PS-MPs) on ovarian function in rats. Particles of PS-MPs were detected in the duodenum and, for the first time, in the different compartments of the ovarian tissue. The toxicity of accumulated PS-MPs was manifested by the reduced relative ovarian weights, by the alteration in the folliculogenesis and in the estrous cycle duration, and by the reduced serum concentration of estradiol. The defective ovarian function following PS-MP treatment might be due to the induction of oxidative stress, which has been proved by an increased malondialdehyde (MDA) concentration and an increased superoxide dismutase (SOD) and catalase (CAT) activities as well as a decreased protein sulfhydryl (PSH) level in the rat ovary. Importantly, by immunofluorescence and RT-PCR, we demonstrated a significant decrease in the expression of cytoskeletal proteins: α-tubulin and disheveled-associated activator of morphogenesis (DAAM-1) in the ovary of rats exposed to PS-MPs at proteomic and transcriptomic levels. Our results uncovered, for the first time, the distribution and accumulation of PS-MPs across rat ovary, revealed a significant alteration in some biomarkers of the ovarian function, and highlighted the possible involvement of MP-induced disturbance of cytoskeleton in these adverse effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.