Evidence map›Paper›PMID 35040017›Full record

ArticleCancer causes & control : CCC2022

Mortality risk and physical activity across the lifespan in endometrial cancer survivors.

Jessica S Gorzelitz, Amy Trentham Dietz, John M Hampton, Ryan J Spencer, Erin Costanzo, Kelli Koltyn, Ronald E Gangnon, Polly A Newcomb, Lisa A Cadmus-Bertram

Abstract read
PubMed Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jessica S GorzelitzDepartment of Kinesiology, University of Wisconsin - Madison, Madison, USA.ORCID http://orcid.org/0000-0001-9230-0593
Amy Trentham DietzDepartment of Population Health Sciences, University of Wisconsin - Madison, Madison, USA.
John M HamptonDepartment of Population Health Sciences, University of Wisconsin - Madison, Madison, USA.
Ryan J SpencerDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, USA.
Erin CostanzoDepartment of Psychiatry, University of Wisconsin - Madison, Madison, USA.
Kelli KoltynDepartment of Kinesiology, University of Wisconsin - Madison, Madison, USA.
Ronald E GangnonDepartment of Population Health Sciences, University of Wisconsin - Madison, Madison, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lisa A Cadmus-BertramDepartment of Kinesiology, University of Wisconsin - Madison, Madison, USA. lisa.bertram@wisc.edu.ORCID http://orcid.org/0000-0003-4835-2817
University of Wisconsin–Madison · USFred Hutch Cancer Center · US

Funding

Feasibility Trial of Home-Based Strength Training in Endometrial Cancer SurvivorsR03CA230965 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CADMUSBERTRAM, LISA ANNE · 2019 to 2020
$148k
6 · The paper itself

Abstract

purposePhysical activity (pre- and post-diagnosis) has been studied in prevention and survivorship contexts for endometrial cancer. However, the association of physical activity (PA) across the lifespan on mortality risk among endometrial cancer survivors is understudied. The study's objective was to identify the association of lifetime PA on mortality risk in endometrial cancer survivors.

methodsSeven hundred forty-five endometrial cancer survivors drawn from a population-based cancer registry (diagnosed between 1991 and 1994) reported the frequency (sessions/week) of moderate- and vigorous intensity physical activity (MVPA) at age 12, age 20, and 5 years pre-interview (post-diagnosis). Cox proportional hazards were used to estimate hazard ratios (HR) and 95% confidence intervals for the association between PA, all-cause, and cardiovascular disease mortality as assessed in 2016. MVPA was modeled using natural cubic splines.

resultsDiagnosis age, body mass index, and smoking (pack-years) were each positively associated with increased all-cause mortality risk. Those who did one session of MVPA 5 years pre-interview had a lower mortality risk (HR 0.61; 95% CI 0.41-0.92) compared to those with no MVPA. Those reporting one session of MVPA was similarly observed at age 12 (HR 0.95; 95% CI 0.86-1.06) and at age 20 (HR 0.87; 95% CI 0.65-1.16).

conclusionThose who participated in PA, compared to those who did not, in the 5 years before diagnosis had a lower mortality risk. While PA was not independently protective against mortality risk at ages 12 or 20, PA is still important for endometrial cancer survivors for other non-mortality outcomes.

Indexed as

Cancer SurvivorsEndometrial NeoplasmsAdultChildExerciseFemaleHumansLongevityRisk FactorsSurvivorsYoung AdultEpidemiologyMeasurementMortalityPhysical activity

Identifiers

PMID35040017
OpenAlexW4206692884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.