Evidence map›Paper›PMID 35039938›Full record

ArticleClinical and experimental medicine2022

Association between serum miR-221-3p and intravenous immunoglobulin resistance in children with Kawasaki disease.

Fengchuan Jing, Haobo Weng, Qiongfei Pei, Jing Zhang, Ruixi Liu, Qijian Yi

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In one paragraph

Article in Clinical and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fengchuan JingDepartment of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Haobo WengDepartment of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Qiongfei PeiDepartment of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Jing ZhangDepartment of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Ruixi LiuDepartment of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. 270815992@qq.com.
Qijian YiDepartment of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. qjyi2003@aliyun.com.ORCID http://orcid.org/0000-0002-4461-3904
China International Science and Technology Cooperation · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIntravenous immunoglobulin (IVIG) resistance was a major cause of coronary artery lesions in children with Kawasaki disease (KD). However, the cause of IVIG resistance in KD remains unknown. miR-221-3p has been confirmed involved in cardiovascular diseases and rheumatoid arthritis. The purpose of this study was to investigate the association between miR-221-3p and IVIG resistance in children with KD.

methodsFifty-five KD patients and 29 healthy controls (HCs) were enrolled in this study. KD patients were divided into group of sensitive to IVIG (IVIG-response, n = 42) and group of resistant to IVIG (IVIG-resistance, n = 13), group of 10 KD patients with coronary artery lesions (CALs, KD-CALs) and group of 10 sex- and age-matched KD patients without CALs (KD-NCALs). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the levels of miR-221-3p.

resultsCompared with the HCs group, miR-221-3p were significantly increased in the KD group (p < 0.05), and the IVIG-resistance group had higher levels of miR-221-3p than those in the IVIG-response group (p < 0.05). CRP (C-reactive protein), PCT (procalcitonin), NLR (neutrophil-lymphocyte ratio) were positively correlated with miR-221-3p in KD patients. In addition, the group of IVIG resistance had a higher level of Kobayashi Score (p < 0.001). The receiver operating characteristic curve showed that miR-221-3p had a better value for diagnosis IVIG resistance in children with KD than Kobayashi Score with the AUC of 0.811 (95% CI, 0.672-0.951), 0.793 (95% CI, 0.618-0.968), respectively. Additionally, miR-221-3p was elevated (p < 0.05) and showed an AUC value of 0.83 (95% CI, 0.648-1.000, p < 0.05) for the prediction of the complication of coronary artery abnormalities in the group of KD with CALs.

conclusionsmiR-221-3p might be involved in the pathogenesis of KD and IVIG resistance and miR-221-3p can be used as a new potential biomarker to predict IVIG resistance in children with KD.

Indexed as

MicroRNAsMucocutaneous Lymph Node SyndromeBiomarkersChildC-Reactive ProteinHumansImmunoglobulins, IntravenousProcalcitoninRetrospective StudiesBiomarkersC-Reactive ProteinImmunoglobulins, IntravenousMicroRNAsMIR221, humanProcalcitoninIntravenous immunoglobulin resistanceKawasaki diseasemicroRNA-221

Identifiers

PMID35039938
OpenAlexW4225565646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.