ArticleNature medicine2022
The value of patient-reported outcomes in early-phase clinical trials.
Abstract read
In one paragraph
Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of patient-reported outcome item libraries in cancer research: an EORTC Quality of Life Group study.Journal of the National Cancer Institute · 2026Pooled it
- Patient-reported outcome (PRO) instruments used in patients undergoing adoptive cell therapy (ACT) for the treatment of cancer: a systematic review.Systematic reviews · 2023Pooled it
- Patient Versus Clinician Reported Symptoms Agreement in Advanced Metastatic Bladder Cancer Patients.Cancer medicine · 2025Trial
- Advancing the Science of Patient Input in Drug Research and Development.Journal of participatory medicine · 2026Article
- International Consensus-Driven Recommendations for Patient-Reported Outcome Research Objectives in Early Phase Dose-Finding Oncology Trials: OPTIMISE-ROR.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026Article
- Application of patient-reported outcomes in clinical trials of traditional Chinese medicine registered in international clinical trials registry platform, from 2010 to 2022: a cross-sectional study.Journal of patient-reported outcomes · 2026Article
- Defining patient-reported outcomes and priorities for clinical trials in CADASIL through an international survey.Cerebral circulation - cognition and behavior · 2026Article
- A personal perspective of patient-centred clinical trials.Oncotarget · 2025Article
- Pragmatic paradigm for patient-reported outcome measure selection in lymphoma clinical trials: a rapid review study.BMJ open · 2025Review
- Review
- Comparison of patient-reported outcomes after uniportal versus multiportal video-assisted thoracoscopic sub-lobar resection.Journal of thoracic disease · 2025Article
- Determining doses for backfill cohorts based on patient-reported outcome.BMC medical research methodology · 2024Article
- Advancing patient-centric care: integrating patient reported outcomes for tolerability assessment in early phase clinical trials - insights from an expert virtual roundtable.EClinicalMedicine · 2024Review
- Development of a quality of life measure for left ventricular assist device recipients using a mixed methods approach.ESC heart failure · 2024Article
- Patient-reported outcome parameters and disability worsening in progressive multiple sclerosis.Multiple sclerosis and related disorders · 2024Article
- Use of the National Cancer Institute Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events to assess treatment tolerability in pulmonary arterial hypertension: qualitative patient research findings in current and former users of oral selexipag.Journal of patient-reported outcomes · 2023Article
- The Assessment of Patient-Reported Outcomes for the Authorisation of Medicines in Europe: A Review of European Public Assessment Reports from 2017 to 2022.Applied health economics and health policy · 2023Review
- Development and usability testing of an electronic patient-reported outcome (ePRO) solution for patients with inflammatory diseases in an Advanced Therapy Medicinal Product (ATMP) basket trial.Journal of patient-reported outcomes · 2023Article
- International Society for Quality of Life Research commentary on the US Food and Drug Administration draft guidance for industry on core patient-reported outcomes in cancer clinical trials.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Analysis of patient-reported outcomes in the approval of novel oncology drugs in the United States, 2017-2022.EClinicalMedicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Ameeta RetzerCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-4156-8386
Olalekan Lee AiyegbusiCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-9122-8251
Anna RoweNational Institute for Health Research Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Philip N NewsomeNational Institute for Health Research Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Jessica Douglas-PughCancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-0189-0933
Sheeba KhanNational Institute for Health Research Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Saloni MittalUniversity of Birmingham, Birmingham, UK.
Roger WilsonNCRI Consumer Forum National Cancer Research Institute, London, UK.ORCID http://orcid.org/0000-0002-6043-7306
Daniel O'ConnorMedicines and Healthcare Products Regulatory Agency (MHRA), London, UK.
Lisa CampbellMedicines and Healthcare Products Regulatory Agency (MHRA), London, UK.
Sandra A MitchellOutcomes Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
Melanie CalvertCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, University of Birmingham, Birmingham, UK. m.calvert@bham.ac.uk.ORCID http://orcid.org/0000-0002-1856-837X
Funding
Cancer Research UK 25354
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clinical Trials as TopicPatient Reported Outcome MeasuresData CollectionHumansResearch Design
Identifiers
PMID
35039659What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.