ArticleNature genetics2022
LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion.
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Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
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Who cites it
56 citing papers in PubMed, 88 citations in OpenAlex.
- Disrupted PQBP1-HNRNPU-LINE-1 axis underlies aberrant neurodevelopment in renpenning syndrome.Molecular psychiatry · 2026Article
- LINE-1 Epigenetic Repression and Regulation of Immunity.Viruses · 2026Review
- AFF3 maintains metabolic quiescence in naive CD8 T cells and prevents premature immune aging.JCI insight · 2026Article
- Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants.Nature genetics · 2026Article
- Transcript-aware rare genetic variant association analyses of cardiopulmonary traits in participants from the All of Us Research Program.Nature communications · 2026Article
- LINE-1 retrotransposons: Multifaceted functions and regulatory mechanisms in health and disease.Molecular therapy. Nucleic acids · 2026Review
- Review
- LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture.Cancer discovery · 2026Article
- miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis.Science advances · 2026Article
- Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles.eLife · 2026Article
- Cryopreservation of siRNA-Treated Cells Is Feasible.Nucleic acid therapeutics · 2025Article
- Molecular effects of transposable element sequences in mammalian cells.Genome biology · 2025Review
- Transposable elements in health and disease: Molecular basis and clinical implications.Chinese medical journal · 2025Review
- Transposable elements as instructors of the immune system.Nature reviews. Immunology · 2025Review
- Expression of LINE-1 elements is required for preimplantation development and totipotency.Genes & diseases · 2025Review
- Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle.bioRxiv : the preprint server for biology · 2025Article
- Guardians of silence: transcriptional networks in T cell quiescence.Experimental & molecular medicine · 2025Review
- Reactivation of retrotransposable elements is associated with environmental stress and ageing.Nature reviews. Genetics · 2025Review
- Inhibition of the LINE1-derivedMolecular therapy. Nucleic acids · 2025Article
- The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma.BMC cancer · 2025Article
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Authors and funding
24 authors at 5 institutions in 1 country.
Federica Marasca *INGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.ORCID http://orcid.org/0000-0002-0699-5323
Shruti Sinha *INGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Rebecca VadalàINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.ORCID http://orcid.org/0000-0002-6781-6958
Benedetto PolimeniINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.ORCID http://orcid.org/0000-0002-7064-7294
Valeria RanzaniINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Elvezia Maria ParaboschiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Filippo Vittorio BurattinINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Marco GhilottiINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.ORCID http://orcid.org/0000-0002-0513-2710
Mariacristina CrostiINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Maria Luce NegriINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Susanna CampagnoliCheckmAb Srl, Milan, Italy.
Samuele NotarbartoloINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Andrea Sartore-BianchiNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Salvatore SienaNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Daniele PratiDepartment of Transfusion Medicine and Hematology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-2281-7498
Giovanni MontiniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-7350-4475
Giuseppe VialeUniversity of Milan, European Institute of Oncology IRCCS, Milan, Italy.
Olga TorreDepartment of Medical Sciences, San Giuseppe Hospital MultiMedica IRCCS, Milan, Italy.
Sergio HarariDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Renata GrifantiniINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Giulia SoldàDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID http://orcid.org/0000-0003-0972-610X
Stefano BiffoINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
Sergio AbrignaniINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy. abrignani@ingm.org.ORCID http://orcid.org/0000-0002-0794-3285
Beatrice BodegaINGM, Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy. bodega@ingm.org.ORCID http://orcid.org/0000-0003-0527-9234
Istituto Nazionale Genetica Molecolare · ITUniversity of Milan · ITHumanitas University · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITMultiMedica · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
How gene expression is controlled to preserve human T cell quiescence is poorly understood. Here we show that non-canonical splicing variants containing long interspersed nuclear element 1 (LINE1) enforce naive CD4
Indexed as
Gene Expression RegulationLong Interspersed Nucleotide ElementsRNA SplicingCD4-Positive T-LymphocytesChromatinHeterogeneous-Nuclear RibonucleoproteinsHistonesHumansInterferon Regulatory Factor-4Interferon Regulatory FactorsLymphocyte ActivationLymphocytes, Tumor-InfiltratingMechanistic Target of Rapamycin Complex 1NucleolinPhosphoproteinsPolypyrimidine Tract-Binding ProteinChromatinHeterogeneous-Nuclear RibonucleoproteinsHistonesInterferon Regulatory Factor-4Interferon Regulatory FactorsMechanistic Target of Rapamycin Complex 1NucleolinPhosphoproteinsPolypyrimidine Tract-Binding ProteinPTBP1 protein, humanRNARNA-Binding ProteinsTranscription Factors, TFIItranscription factor TFIIF
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