Evidence map›Paper›PMID 35039629›Full record

Observational studyEuropean journal of clinical nutrition2022

Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake.

Emily Jeffery, Y C Gary Lee, Robert U Newton, Philippa Lyons-Wall, Joanne McVeigh, Deirdre B Fitzgerald, Leon Straker, Carolyn J Peddle-McIntyre

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Malignant pleural disease.Breathe (Sheffield, England) · 2023
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Emily JefferyExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia. emily.jeffery@curtin.edu.au.ORCID http://orcid.org/0000-0002-9463-3196
Y C Gary LeeRespiratory Department, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0003-0302-6129
Philippa Lyons-WallSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Joanne McVeighSchool of Allied Health, Curtin University, Perth, WA, Australia.
Deirdre B FitzgeraldRespiratory Department, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Leon StrakerSchool of Allied Health, Curtin University, Perth, WA, Australia.ORCID http://orcid.org/0000-0002-7786-4128
Carolyn J Peddle-McIntyreExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Edith Cowan University · AUCurtin University · AUSir Charles Gairdner Hospital · AUThe University of Western Australia · AUUniversity of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkeletal muscle loss is common in advanced cancer and is associated with negative outcomes. In malignant pleural mesothelioma (MPM), no study has reported body composition changes or factors associated with these changes. This study aimed to describe changes in body composition over time and its relationship with activity levels, dietary intake and survival.

methodsThe study was a secondary analysis of data collected from a longitudinal observational study of patients with MPM. Participants completed 3-month assessments for up to 18 months. Participants with two dual-energy x-ray absorptiometry (DXA) scans were included. Changes in appendicular skeletal muscle mass (ASM) and total fat mass were used to categorise participants into phenotypes. Activity levels were measured with an ActiGraph GT3X+ accelerometer and energy and protein intake was measured with a 3-day food record and 24-h recall.

resultsEighteen participants were included (89% men, mean age 68.9 ± 7.1 years). Median time between DXA was 91 [IQR 84-118] days. Compared to participants with ASM maintenance (n = 9), fewer participants with ASM loss (n = 9) survived ≥12 months from follow-up (p = 0.002). Participants with ASM loss increased sedentary time (p = 0.028) and decreased light activity (p = 0.028) and step count (p = 0.008). Activity levels did not change in participants with ASM maintenance (p > 0.05). Energy and protein intake did not change in either group (p > 0.05).

conclusionsMuscle loss was associated with poorer survival and decreased activity levels. Interventions that improve physical activity or muscle mass could benefit patients with MPM.

Indexed as

Mesothelioma, MalignantAbsorptiometry, PhotonBody CompositionBody Mass IndexEatingHumansMuscle, Skeletal

Identifiers

PMID35039629
PMCPMC9270221
OpenAlexW4205891765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.