ArticleScientific reports2022
A computational analysis of atrial fibrillation effects on coronary perfusion across the different myocardial layers.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Correlation of epicardial adipose tissue with microvascular obstruction and its effect on new-onset atrial arrhythmias after PCI in STEMI patients.Scientific reports · 2025Article
- Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.NPJ microgravity · 2024Article
- Risk of myocardial infarction and ischemic stroke in individuals with first-diagnosed paroxysmal vs. non-paroxysmal atrial fibrillation under anticoagulation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Arterial wave dynamics preservation upon orthostatic stress: a modelling perspective.Royal Society open science · 2023Article
- Atrial fibrillation episode status and incidence of coronary slow flow: A propensity score-matched analysis.Frontiers in cardiovascular medicine · 2023Article
- Cardiovascular Response to Posture Changes: Multiscale Modeling andFrontiers in physiology · 2022Article
- Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke.Frontiers in cardiovascular medicine · 2022Review
- Insights from computational modeling on the potential hemodynamic effects of sinus rhythm versus atrial fibrillation.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with atrial fibrillation (AF) may present ischemic chest pain in the absence of classical obstructive coronary disease. Among the possible causes, the direct hemodynamic effect exerted by the irregular arrhythmia has not been studied in detail. We performed a computational fluid dynamics analysis by means of a 1D-0D multiscale model of the entire human cardiovascular system, enriched by a detailed mathematical modeling of the coronary arteries and their downstream distal microcirculatory districts (subepicardial, midwall and subendocardial layers). Three mean ventricular rates were simulated (75, 100, 125 bpm) in both sinus rhythm (SR) and atrial fibrillation, and an inter-layer and inter-frequency analysis was conducted focusing on the ratio between mean beat-to-beat blood flow in AF compared to SR. Our results show that AF exerts direct hemodynamic consequences on the coronary microcirculation, causing a reduction in microvascular coronary flow particularly at higher ventricular rates; the most prominent reduction was seen in the subendocardial layers perfused by left coronary arteries (left anterior descending and left circumflex arteries).
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