ArticleScientific reports2022
A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
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- Concentration-Dependent Rheological Properties of Atelocollagen Are Associated with Fibroblast Mechanotransduction and Collagen Remodeling in Aged Skin.Journal of functional biomaterials · 2026Article
- Noncircadian BMAL1-YAP activity amplifies persistent inflammation in aged epidermis.Nature aging · 2026Article
- Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging.Scientific reports · 2026Article
- Finite element modeling of inter-individual variation in soft tissue mechanical response to localized pressure.Biomechanics and modeling in mechanobiology · 2026Article
- Collagen Mechanics.Sub-cellular biochemistry · 2026Review
- A neuromorphic robotic electronic skin with active pain and injury perception.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Atomic force microscope protocols for characterising the elastoviscoplastic biomechanical properties of corneocytes.Communications biology · 2025Article
- Assessment of dermal fiber changes associated with age ethnicity and cosmetic product use by LC-OCT and automated 3D segmentation.Scientific reports · 2025Article
- Evaluation of Improvement in Skin Laxity and Oiliness After Monopolar Radiofrequency Treatment: A Pilot Study Utilizing Multiple Assessment Tools.Journal of cosmetic dermatology · 2025Article
- A microneedle device for rapid dermal interstitial fluid sampling.Science advances · 2025Article
- Influence of aging on dermal elastin fiber architecture and skin firmness assessed by finite element modeling.Scientific reports · 2025Article
- Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration.Advanced healthcare materials · 2025Article
- Shaping epithelial tissues by stem cell mechanics in development and cancer.Nature reviews. Molecular cell biology · 2025Review
- Fabrication of Multiscale, Multidirectional Orientated Collagen Hydrogels with Guided Cell Alignment Using Fluidics and a Three-Dimensional Printing.ACS biomaterials science & engineering · 2025Article
- Multimodal Second-Harmonic-Generation, Two-Photon Excitation Fluorescence, and Brillouin Microscopy for Visualising Dermal Mechanical Properties in Ex Vivo Human Skin.Experimental dermatology · 2025Article
- Expansion limits of meshed split-thickness skin grafts.Acta biomaterialia · 2025Article
- Effects of Exosomes From Hypoxia-Induced Adipose-Derived Stem Cells on Ameliorating Photoaging.Clinical, cosmetic and investigational dermatology · 2025Article
- Quasi-Static Mechanical Biomimetics Evaluation of Car Crash Dummy Skin.Biomimetics (Basel, Switzerland) · 2024Article
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Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related changes in skin mechanics have a major impact on the aesthetic perception of skin. The link between skin microstructure and mechanics is crucial for therapeutic and cosmetic applications as it bridges the micro- and the macro-scale. While our perception is governed by visual and tactile changes at the macroscopic scale, it is the microscopic scale (molecular assemblies, cells) that is targeted by topical treatments including active compounds and energies. We report here a large dataset on freshly excised human skin, and in particular facial skin highly relevant for cosmetics and aesthetic procedures. Detailed layer-by-layer mechanical analysis revealed significant age-dependent decrease in stiffness and elastic recoil of full-thickness skin from two different anatomical areas. In mammary skin, we found that the onset of mechanical degradation was earlier in the superficial papillary layer than in the deeper, reticular dermis. These mechanical data are linked with microstructural alterations observed in the collagen and elastic networks using staining and advanced imaging approaches. Our data suggest that with ageing, the earliest microstructural and mechanical changes occur in the top-most layers of dermis/skin and then propagate deeper, providing an opportunity for preventive topical treatments acting at the level of papillary dermis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.