ArticleScientific reports2022
Accuracy of vascular tortuosity measures using computational modelling.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Optimising Generalisable Deep Learning Models for CT Coronary Segmentation: A Multifactorial Evaluation.Journal of imaging informatics in medicine · 2026Article
- Effect of Angiographic Hemodynamic Parameters and Vascular Tortuosity on In-Stent Restenosis in Intracranial Atherosclerosis.Clinical neuroradiology · 2026Article
- A Machine Learning Driven Approach to Quantifying Coronary Artery Tortuosity.JACC. Advances · 2026Article
- Information Entropy-Based Framework for Quantifying Curve Tortuosity in Meibomian Glands Uneven Atrophy.Translational vision science & technology · 2026Article
- Design Rules for Robust Coronary Artery Segmentation: A Systematic Analysis of Dataset Size, Windowing, Architectures, and Vessel Geometry.Annals of biomedical engineering · 2026Article
- Computer-aided assessment of intracranial arterial tortuosity as a predictor of aneurysm occurrence and instability.Neuroradiology · 2026Article
- Automated segmentation and quantitative analysis of vascular curvature features in unruptured intracranial aneurysms based on time-of-flight magnetic resonance angiography (TOF-MRA).Quantitative imaging in medicine and surgery · 2026Article
- High-intensity helical flow: a double-edged sword in coronary artery haemodynamics.Royal Society open science · 2025Article
- SmartPlus: a computer-based image analysis method to predict continuous-valued vascular abnormality index in Retinopathy of Prematurity.International journal of retina and vitreous · 2025Article
- Less is more: selection from a small set of options improves BCI velocity control.Journal of neural engineering · 2025Article
- Advancements in Glass Fiber Separator Technology for Lithium-Sulfur Batteries: The Role of Transport, Material Properties, and Modifications.ACS omega · 2025Review
- Sensitivity of coronary hemodynamics to vascular structure variations in health and disease.Scientific reports · 2025Article
- Assessing left main bifurcation anatomy and haemodynamics as a potential surrogate for disease risk in suspected coronary artery disease without stenosis.Scientific reports · 2025Article
- Nomogram-Based Prediction of 3-Month Unfavorable Outcome and Early Neurological Deterioration After Endovascular Thrombectomy in Acute Ischemic Stroke.Therapeutics and clinical risk management · 2025Article
- Measuring arterial tortuosity in the cerebrovascular system using Time-of-Flight MRI.medRxiv : the preprint server for health sciences · 2024Article
- A new understanding of coronary curvature and haemodynamic impact on the course of plaque onset and progression.Royal Society open science · 2024Article
- Magnetic resonance lymphangiography: Establishing normal.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Less is more: selection from a small set of options improves BCI velocity control.bioRxiv : the preprint server for biology · 2024Article
- Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden.Scientific reports · 2024Article
- Automated diagnosis of plus disease in retinopathy of prematurity using quantification of vessels characteristics.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe coronary tortuosity has previously been linked to low shear stresses at the luminal surface, yet this relationship is not fully understood. Several previous studies considered different tortuosity metrics when exploring its impact of on the wall shear stress (WSS), which has likely contributed to the ambiguous findings in the literature. Here, we aim to analyze different tortuosity metrics to determine a benchmark for the highest correlating metric with low time-averaged WSS (TAWSS). Using Computed Tomography Coronary Angiogram (CTCA) data from 127 patients without coronary artery disease, we applied all previously used tortuosity metrics to the left main coronary artery bifurcation, and to its left anterior descending and left circumflex branches, before modelling their TAWSS using computational fluid dynamics (CFD). The tortuosity measures included tortuosity index, average absolute-curvature, root-mean-squared (RMS) curvature, and average squared-derivative-curvature. Each tortuosity measure was then correlated with the percentage of vessel area that showed a < 0.4 Pa TAWSS, a threshold associated with altered endothelial cell cytoarchitecture and potentially higher disease risk. Our results showed a stronger correlation between curvature-based versus non-curvature-based tortuosity measures and low TAWSS, with the average-absolute-curvature showing the highest coefficient of determination across all left main branches (p < 0.001), followed by the average-squared-derivative-curvature (p = 0.001), and RMS-curvature (p = 0.002). The tortuosity index, the most widely used measure in literature, showed no significant correlation to low TAWSS (p = 0.86). We thus recommend the use of average-absolute-curvature as a tortuosity measure for future studies.
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