ArticleNature communications2022
Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 70 citations in OpenAlex.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Prefrontal-raphe-habenular circuit drives fear memory recall and updating.Nature communications · 2026Article
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- vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choices.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal cortical deficits are a putative susceptibility factor for PTSD.Frontiers in behavioral neuroscience · 2026Article
- Efficacy of Venlafaxine and Deep Brain Stimulation Against the Effects of Hippocampal Lesion with Ibotenic Acid in Animals Exposed to the Chronic Mild Stress Model of Depression.Current neuropharmacology · 2026Article
- Review
- Pairing extinction training with vagus nerve stimulation reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.Frontiers in neuroscience · 2026Article
- The role of the anterior cingulate cortex in anxiety control, from circuits to disorders.Frontiers in psychiatry · 2026Review
- Pairing extinction training with vagus nerve stimulation (VNS) reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions.Nature communications · 2025Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
- Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in 3xTg Alzheimer's model mice.Communications biology · 2025Article
- Article
- Overcoming Automatic Behavioral Tendencies in Approach-Avoidance Conflict Decisions.Psychophysiology · 2025Article
- Article
- Dorsal-Caudal and Ventral Hippocampi Target Different Cell Populations in the Medial Frontal Cortex in Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Differential neural decoding of alarm and avoidance information from vocal alarm calls in humans.Communications biology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The decision to either approach or avoid a potentially threatening environment is thought to rely upon the coordinated activity of heterogeneous neural populations in the hippocampus and prefrontal cortex (PFC). However, how this circuitry is organized to flexibly promote both approach or avoidance at different times has remained elusive. Here, we show that the hippocampal projection to PFC is composed of two parallel circuits located in the superficial or deep pyramidal layers of the CA1/subiculum border. These circuits have unique upstream and downstream connectivity, and are differentially active during approach and avoidance behaviour. The superficial population is preferentially connected to widespread PFC inhibitory interneurons, and its activation promotes exploration; while the deep circuit is connected to PFC pyramidal neurons and fast spiking interneurons, and its activation promotes avoidance. Together this provides a mechanism for regulation of behaviour during approach avoidance conflict: through two specialized, parallel circuits that allow bidirectional hippocampal control of PFC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.