ArticleNature communications2022
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- CYP82G1 Enzyme Functions as Chromone Hydroxylase in the Biosynthesis of 6-Hydroxy-2-(2-Phenylethyl)chromone in Aquilaria sinensis.Plant biotechnology journal · 2025Article
- Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.Plant biotechnology journal · 2025Article
- Genomic and chemical profiling of Botryosphaeria dothidea: cryptic biosynthetic gene clusters and secondary metabolites in agarwood formation.The Journal of antibiotics · 2025Article
- Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants.Nature communications · 2025Article
- Biosynthesis and Its Regulatory Mechanisms of 2-(2-Phenylethyl)chromones in Agarwood.Plants (Basel, Switzerland) · 2025Review
- Characteristics of Growth, Photosynthesis, C/N Ratio, and Antioxidant Capacity in the Seedling Stage ofPlants (Basel, Switzerland) · 2025Article
- Practical Preparation of (3International journal of molecular sciences · 2025Article
- Towards sustainable agarwood production: integrating microbial interactions, anatomical changes, and metabolite biosynthesis.Journal of industrial microbiology & biotechnology · 2024Review
- Article
- Discovery of plant chemical defence mediated by a two-component system involving β-glucosidase in Panax species.Nature communications · 2024Article
- Article
- Comprehensive Analysis ofInternational journal of molecular sciences · 2023Article
- Biosynthesis of barley wax β-diketones: a type-III polyketide synthase condensing two fatty acyl units.Nature communications · 2023Article
- Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood.Journal of natural medicines · 2023Review
- How Closely Does Induced Agarwood's Biological Activity Resemble That of Wild Agarwood?Molecules (Basel, Switzerland) · 2023Article
- Article
- Comprehensive Comparisons between Grafted Kynam Agarwood and Normal Agarwood on Traits, Composition, and In Vitro Activation of AMPK.Molecules (Basel, Switzerland) · 2023Article
- Repeated mechanical damage enhancedFrontiers in plant science · 2023Article
- Systematic evolution ofFrontiers in plant science · 2023Article
- Functional characterization of key polyketide synthases by integrated metabolome and transcriptome analysis on curcuminoid biosynthesis inSynthetic and systems biotechnology · 2022Article
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2-(2-Phenylethyl)chromones (PECs) are the principal constituents contributing to the distinctive fragrance of agarwood. How PECs are biosynthesized is currently unknown. In this work, we describe a diarylpentanoid-producing polyketide synthase (PECPS) identified from Aquilaria sinensis. Through biotransformation experiments using fluorine-labeled substrate, transient expression of PECPS in Nicotiana benthamiana, and knockdown of PECPS expression in A. sinensis calli, we demonstrate that the C
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