ArticleJournal of clinical pathology2023
Faster than light (microscopy): superiority of digital pathology over microscopy for assessment of immunohistochemistry.
Article in Journal of clinical pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Accelerating the implementation of digital pathology in India.Journal of pathology informatics · 2026Review
- Enhancing histology education: Iranian medical students' experience with eHistoLab web-application virtual microscopy.BMC medical education · 2026Article
- The evolving role of DICOM in digital pathology.Journal of pathology informatics · 2026Review
- The patient matters: a roundtable discussion on pathology in the era of digitization and AI.Virchows Archiv : an international journal of pathology · 2026Article
- Digital transformation of pathology - the European Society of Pathology expert opinion paper.Virchows Archiv : an international journal of pathology · 2025Article
- Development of a national pathology training system using digital pathology and SNOMED-CT.Journal of pathology informatics · 2025Article
- Deep learning models for cervical cancer subtyping using whole slide images.Frontiers in oncology · 2025Article
- Applications of artificial intelligence in digital pathology for gastric cancer.Frontiers in oncology · 2024Review
- Synergies and Challenges in the Preclinical and Clinical Implementation of Pathology Artificial Intelligence Applications.Mayo Clinic proceedings. Digital health · 2023Review
- Virtual Versus Light Microscopy Usage among Students: A Systematic Review and Meta-Analytic Evidence in Medical Education.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDigital pathology offers the potential for significant benefits in diagnostic pathology, but currently the efficiency of slide viewing is a barrier to adoption. We hypothesised that presenting digital slides for simultaneous viewing of multiple sections of tissue for comparison, as in those with immunohistochemical panels, would allow pathologists to review cases more quickly.
methodsNovel software was developed to view synchronised parallel tissue sections on a digital pathology workstation. Sixteen histopathologists reviewed three liver biopsy cases including an immunohistochemical panel using the digital microscope, and three different liver biopsy cases including an immunohistochemical panel using the light microscope. The order of cases and interface was fully counterbalanced. Time to diagnosis was recorded and mean times are presented as data approximated to a normalised distribution.
resultsMean time to diagnosis was 4 min 3 s using the digital microscope and 5 min 24 s using the light microscope, saving 1 min 21 s (95% CI 16 s to 2 min 26 s; p=0.02), using the digital microscope. Overall normalised mean time to diagnosis was 85% on the digital pathology workstation compared with 115% on the microscope, a relative reduction of 26%.
conclusionsWith appropriate interface design, it is quicker to review immunohistochemical slides using a digital microscope than the conventional light microscope, without incurring any major diagnostic errors. As digital pathology becomes more integrated with routine clinical workflow and pathologists increase their experience of the technology, it is anticipated that other tasks will also become more time-efficient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.