Evidence map›Paper›PMID 35038930›Full record

ArticleVeterinary pathology2022

Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.

David S Rotstein, Sarah Peloquin, Kathleen Proia, Ellen Hart, Jeongha Lee, Kristin K Vyhnal, Emi Sasaki, Gayathriy Balamayooran, Javier Asin, Teresa Southard and 17 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 10 institutions in 1 country.

David S RotsteinUS Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Rockville, MD, USA.ORCID 0000-0002-1486-4972
Sarah PeloquinUS Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Veterinary Laboratory Investigation and Response Network, Laurel, MD, USA.
Kathleen ProiaUS Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Veterinary Laboratory Investigation and Response Network, Laurel, MD, USA.
Ellen HartUS Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Rockville, MD, USA.
Jeongha LeeLouisiana State University, Baton Rouge, LA, USA.
Kristin K VyhnalLouisiana State University, Baton Rouge, LA, USA.ORCID 0000-0002-9086-4165
Emi SasakiLouisiana State University, Baton Rouge, LA, USA.
Gayathriy BalamayooranTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
Javier AsinUniversity of California-Davis, San Bernardino, CA, USA.
Teresa SouthardCornell University, Ithaca, NY, USA.ORCID 0000-0001-8388-7951
Laura RothfeldtArkansas Department of Health, Zoonotic Disease Section, Little Rock, AR, USA.ORCID 0000-0002-3562-9664
Heather VenkatCenter for Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Peter MundschenkArizona Department of Agriculture, Phoenix, AZ, USA.
Darby McDermottNew Jersey Department of Health, Communicable Disease Service, Trenton, NJ, USA.
Beate CrossleyUniversity of California-Davis, San Bernardino, CA, USA.
Pamela FerroTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
Gabriel GomezTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
Eileen H HendersonUniversity of California-Davis, San Bernardino, CA, USA.
Paul NarayanTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
Daniel B PaulsenLouisiana State University, Baton Rouge, LA, USA.
Steven RekantUSDA APHIS Veterinary Services, Riverdale, MD, USA.ORCID 0000-0002-7358-1091
Megan E SchroederTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA.
Rachel M TellUSDA National Veterinary Services Laboratories, Ames, IA, USA.ORCID 0000-0001-5403-225X
Mia Kim TorchettiUSDA National Veterinary Services Laboratories, Ames, IA, USA.
Francisco A UzalUniversity of California-Davis, San Bernardino, CA, USA.
Ann CarpenterCenters for Disease Control and Prevention, Atlanta, GA, USA.
Ria GhaiCenters for Disease Control and Prevention, Atlanta, GA, USA.
Wellborn Road Veterinary Medical Center · USCalifornia State University, San Bernardino · USCenter for Veterinary Medicine · USLouisiana State University · USCenters for Disease Control and Prevention · USNational Animal Disease Center · USAnimal and Plant Health Inspection Service · USArkansas Department of Health · USCornell University · USNew Jersey Department of Health · US

Funding

CVM Vet-LRN Veterinary Diagnostic Laboratory ProgramU18FD006173 · FDA · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI ALMA ROY · 2017 to 2026
$630k
Studies on Antimicrobial resistance in bacteria of veterinary importanceU18FD006379 · FDA · CORNELL UNIVERSITY · PI ALTIER, CRAIG · 2018 to 2022
$300k
Microbiology testing support for VetLIRNU18FD006161 · FDA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KATHY Lynn KURTH · 2017 to 2026
$265k
FDA HHS U18 FD006161FDA HHS U18 FD006173FDA HHS U18 FD006379
6 · The paper itself

Abstract

Documented natural infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exotic and companion animals following human exposures are uncommon. Those documented in animals are typically mild and self-limiting, and infected animals have only infrequently died or been euthanized. Through a coordinated One Health initiative, necropsies were conducted on 5 animals from different premises that were exposed to humans with laboratory-confirmed SARS-CoV-2 infection. The combination of epidemiologic evidence of exposure and confirmatory real-time reverse transcriptase-polymerase chain reaction testing confirmed infection in 3 cats and a tiger. A dog was a suspect case based on epidemiologic evidence of exposure but tested negative for SARS-CoV-2. Four animals had respiratory clinical signs that developed 2 to 12 days after exposure. The dog had bronchointerstitial pneumonia and the tiger had bronchopneumonia; both had syncytial-like cells with no detection of SARS-CoV-2. Individual findings in the 3 cats included metastatic mammary carcinoma, congenital renal disease, and myocardial disease. Based on the necropsy findings and a standardized algorithm, SARS-CoV-2 infection was not considered the cause of death in any of the cases. Continued surveillance and necropsy examination of animals with fatal outcomes will further our understanding of natural SARS-CoV-2 infection in animals and the potential role of the virus in development of lesions.

Indexed as

COVID-19Dog DiseasesOne HealthAnimalsDogsPetsSARS-CoV-2bronchopneumoniacatsCOVID-19dogsrespiratorysevere acute respiratory syndrome coronavirus 2syncytial celltigerviralzoonosis

Identifiers

PMID35038930
PMCPMC9207983
OpenAlexW4205547716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.