Evidence map›Paper›PMID 35038926›Full record

ArticlemBio2022

Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction.

Miranda J Wallace, Sophonie Jean, Meghan A Wallace, Carey-Ann D Burnham, Gautam Dantas

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Diverse Genomic Mechanisms ofAntibiotics (Basel, Switzerland) · 2026
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  2. Comparative genomic analysis ofMicrobiology spectrum · 2026
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  5. Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025
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  8. The Emergence ofMicroorganisms · 2025
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  9. Clinical Outcomes and Molecular Characteristics ofAnnals of laboratory medicine · 2025
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  10. Prophages inHeliyon · 2025
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  11. Megaprosthesis Infection byClinical case reports · 2025
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  14. Pangenome comparison ofmSystems · 2024
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  15. Broad-range amplification and sequencing of theJournal of clinical microbiology · 2024
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  16. PathogenicbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Pangenome comparison ofbioRxiv : the preprint server for biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Miranda J Wallace *Department of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3036-4545
Sophonie Jean *Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0001-9372-3491
Meghan A WallaceDepartment of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Carey-Ann D BurnhamDepartment of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1137-840X
Gautam DantasDepartment of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-0455-8370
Washington University in St. Louis · USNationwide Children's Hospital · US

Funding

MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
Impact of early-life perturbations on pediatric microbiome maturationR01AI155893 · NIAID · WASHINGTON UNIVERSITY · PI Gautam Dantas · 2021 to 2026
$4.6M
STRUCTURAL, MECHANISTIC, & EVOLUTIONARY CHARACTERIZATION OF TETRACYCLINE DESTRUCTASESU01AI123394 · NIAID · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, WENCEWICZ, TIMOTHY ADAM · 2020 to 2025
$4.1M
Environmental hygiene strategies to decrease the burden of antibiotic-resistant organisms in Intensive Care Unit SINKs (ICU SINK)R01HS027621 · AHRQ · WASHINGTON UNIVERSITY · PI BURNHAM, CAREY-ANN DAWN, DANTAS, GAUTAM · 2020 to 2024
$2.4M
AHRQ HHS R01 HS027621NCI NIH HHS T32 CA113275NIAID NIH HHS R01 AI155893NIAID NIH HHS U01 AI123394
6 · The paper itself

Abstract

Bacteroides fragilis group (BFG) are the most frequently recovered anaerobic bacteria from human infections, and resistance to frontline antibiotics is emerging. In the absence of routine antimicrobial susceptibility testing (AST) for BFG in most clinical settings, we assessed the utility of clinical and modern genomics tools to determine BFG species-level identification and resistance patterns. A total of 174 BFG clinical isolates supplemented with 20 archived carbapenem-resistant B. fragilis

Indexed as

BacteroidesBacteroides InfectionsAnti-Bacterial AgentsBacteroides fragilisCarbapenemsGenomicsHumansMicrobial Sensitivity TestsPhylogenySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAnti-Bacterial AgentsCarbapenemsanaerobesantibiotic resistanceBacteroidesbeta-lactamscarbapenemsgenomicsmass spectrometrytaxonomy

Identifiers

PMID35038926
PMCPMC8764542
OpenAlexW4205497314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.