ArticlemBio2022
High-Level Acquisition of Maternal Oral Bacteria in Formula-Fed Infant Oral Microbiota.
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pooled it
- Maternal influences on oral microbiome development and implications for early childhood health: a systematic review.Infection and immunity · 2026Pooled it
- Black Hairy Tongue in a 54-Day-Old Infant: A Case Report.Clinical case reports · 2026Article
- Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases.Medical review (2021) · 2026Review
- Unique ecology of co-occurring functionally and phylogenetically undescribed species in the infant oral microbiome.PLoS computational biology · 2026Article
- Effects of 4-week xylitol tablet intake on tongue microbiota composition in children: a single-arm pilot study.Microbiology spectrum · 2026Article
- Characterization of subgingival plaque microbiota in patients with severe periodontitis using full-length 16S rRNA gene sequencing.Scientific reports · 2025Article
- Exploratory study of the oral microbiota in pregnant women with hypothyroidism and their infants.BMC pregnancy and childbirth · 2025Article
- Expert consensus on the treatment of oral diseases in pregnant women and infants.International journal of oral science · 2025Review
- Transmission of maternal oral pathobionts to the infant gut predisposes offspring to exacerbated enteritis.Cell reports · 2025Article
- Intraspecies dynamics underlie the apparent stability of two important skin microbiome species.Cell host & microbe · 2025Article
- Previously hidden intraspecies dynamics underlie the apparent stability of two important skin microbiome species.bioRxiv : the preprint server for biology · 2025Article
- Performance of salivary microbiota in detecting periodontitis using a machine learning approach.Frontiers in cellular and infection microbiology · 2025Article
- Acquisition of the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Perinatal factors influencing the earliest establishment of the infant microbiome.Microbiome research reports · 2025Article
- Association of oral fungal profiles with health status and bacterial composition in elderly adults receiving community support and home care service.Applied and environmental microbiology · 2024Article
- Article
- Microbiota, metabolic profiles and immune biomarkers in infants receiving formula with added bovine milk fat globule membrane: a randomized, controlled trial.Frontiers in nutrition · 2024Article
- Oral-to-rectum microbial transmission in orthopedic patients without a history of intestinal disorders.Frontiers in cellular and infection microbiology · 2024Article
- Comparative analysis based on shared amplicon sequence variants reveals that cohabitation influences gut microbiota sharing between humans and dogs.Frontiers in veterinary science · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influx of maternal oral microbes is considered to play an important role in the acquisition and development of infant oral microbiota. In this study, we examined tongue swab samples from 448 mother-infant pairs at 4-month checkups. The bacterial composition of each sample was determined using PacBio single-molecule long-read sequencing of the full-length 16S rRNA gene and the amplicon sequence variant (ASV) approach. Although the infant oral microbiota was distinctly different from the mother oral microbiota, ASVs shared with their biological mother accounted for a median relative abundance of 9.7% (range of 0.0 to 99.3%), which was significantly higher than that of ASVs shared with unrelated mothers. This shared abundance was strongly associated with the feeding method of infants rather than their delivery mode or antibiotic exposure, and formula-fed infants had higher shared abundance than exclusively breastfed infants. Our study presents strain-level evidence for mother-to-infant transmission of oral bacteria and suggests that colonization of maternal oral bacteria is higher in formula-fed infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.