ArticlemBio2022
JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis.
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Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Generation of G9 genotype porcine rotavirus using reverse genetics system and its application for antiviral screen and vaccine development.Virologica Sinica · 2026Article
- JIB-04, an inhibitor of Jumonji histone demethylase as a potent antitubercular agent against Mycobacterium tuberculosis.Archives of microbiology · 2024Article
- Article
- CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner.PLoS biology · 2023Article
- The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein.Frontiers in microbiology · 2023Article
- Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal.Journal of biomedical science · 2022Review
- Recent Advances with KDM4 Inhibitors and Potential Applications.Journal of medicinal chemistry · 2022Review
- The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs.Microorganisms · 2022Review
- Recent advances in developing small-molecule inhibitors against SARS-CoV-2.Acta pharmaceutica Sinica. B · 2022Review
- Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies.Cells · 2022Review
- Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses.mBio · 2021Review
- Early COVID-19 therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in outpatient settings significantly improved COVID-19 outcomes compared to known outcomes in untreated patients.New microbes and new infections · 2021Article
- Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms.Molecular cell · 2021Article
- The biogenesis of SARS-CoV-2 spike glycoprotein: multiple targets for host-directed antiviral therapy.Biochemical and biophysical research communications · 2021Review
Corrections and comments
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Authors and funding
31 authors at 7 institutions in 2 countries.
Juhee Son *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-9605-7017
Shimeng Huang *Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Qiru Zeng *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Traci L BrickerDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
James Brett CaseDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-7331-5511
Jinzhu ZhouInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Ruochen ZangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Zhuoming LiuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Xinjian ChangInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Tamarand L DarlingDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Jian XuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Houda H HarastaniDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Lu ChenNational Center for Advancing Translational Sciencesgrid.429651.d, National Institutes of Health, Rockville, Maryland, USA.
Maria Florencia Gomez CastroDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Yongxiang ZhaoInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Hinissan P KohioDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Gaopeng HouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Baochao FanInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Beibei NiuInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Rongli GuoInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.
Paul W RothlaufDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Adam L BaileyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Xin WangKey Laboratory of Marine Drugs, Ministry of Education, Ocean University of Chinagrid.4422.0, Qingdao, China.
Pei-Yong ShiDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Elisabeth D MartinezDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, USA.
Steven L BrodyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Sean P J WhelanDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1564-8590
Michael S DiamondDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Adrianus C M BoonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-4700-8224
Bin LiInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation, Base of Ministry of Science and Technology, Nanjing, China.ORCID 0000-0003-1318-7081
Siyuan DingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-5338-260X
Washington University in St. Louis · USJiangsu Academy of Agricultural Sciences · CNHarvard University · USNational Institutes of Health · USOcean University of China · CNSouthwestern Medical Center · USThe University of Texas Medical Branch at Galveston · US
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MCOVID Supplement B Cell Epitope Discovery and Mechanisms of Antibody Protection.75N93019C00062 · NIAID · WASHINGTON UNIVERSITY · PI FREMONT, DAVED · 2019 to 2023
$11.7MEmerging infections: surveillance, epidemiology and pathogenesisU01AI151810 · NIAID · WASHINGTON UNIVERSITY · PI Adrianus CM Boon, DAVID WANG · 2020 to 2026
$10.0MRNA Processing in Non-Segmented Minus-Strand RNA VirusesR37AI059371 · NIAID · WASHINGTON UNIVERSITY · PI WHELAN, SEAN PJ · 2015 to 2024
$5.4MHuman neutralizing antibodies for Zika virusR01AI127828 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2017 to 2021
$3.9MInterferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral AntagonismR01AI150796 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2024
$2.0MGenetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionR00AI135031 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2021
$498kEpigenetic reprogramming of the malaria parasiteR21AI139408 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MARTINEZ, ELISABETH D · 2020 to 2021
$449kGenetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionK99AI135031 · NIAID · STANFORD UNIVERSITY · PI DING, SIYUAN · 2018 to 2018
$132kNIAID NIH HHS 75N93019C00062NIAID NIH HHS K99 AI135031NIAID NIH HHS R00 AI135031NIAID NIH HHS R01 AI127828NIAID NIH HHS R01 AI150796NIAID NIH HHS R21 AI139408NIAID NIH HHS R37 AI059371NIAID NIH HHS U01 AI151810NIDDK NIH HHS P30 DK052574
Abstract
Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified small-molecule inhibitors that potently block the replication of severe acute respiratory syndrome virus 2 (SARS-CoV-2). Among them, JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with a 50% effective concentration of 695 nM, with a specificity index of greater than 1,000. JIB-04 showed
Indexed as
COVID-19SARS-CoV-2AminopyridinesAnimalsAntiviral AgentsChlorocebus aethiopsHumansHydrazonesSwineVero CellsVirus ReplicationAminopyridinesAntiviral AgentsHydrazonesJIB-04antiviral agentscoronavirusJIB-04SARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.